Team:Warsaw

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<h1>A novel system for generation and screening for new interactors targeted against any bait</h1>
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<div align="center"><img src="https://static.igem.org/mediawiki/2008/6/61/IGEMUWteam-small.gif"/></div>
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<p><ul>
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<p>Our team consists of 9 students of Faculty of Biology, University of
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<li>maximization of interaction between given bait and randomly generated protein by mutating sequence of the latter</li><li>
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Warsaw. This is the first time a group from Poland participates in the
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interactor presentation on bacterial surface</li><li>
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iGEM competition. Our plans were really amazing: we wanted to create
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selection of best bait interactor</li>
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system of biological machines which would allow to investigate protein
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interactions and simultaneously change sequence of one of them in
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order to achieve the strongest possible interaction. To make it work
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we planned to express the tested protein in a bacterial strain in
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<div align="center"><img src="https://static.igem.org/mediawiki/2008/6/6a/Krag_zycia2.gif" usemap="#Map"/>
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which it would be mutated. Selection would occur outside outer
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bacterial membrane, where the protein would be attached. We planned
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that such selection system would allow us to search for antibodies
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with new specificities or screen protein libraries. </p></td>
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<h2>Institutions whom we would like to thank for financial and technical support:</h2>
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<h3>Institutions whom we would like to thank for financial and technical support:</h3>
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     <td align="center" valign="bottom"><a href="http://www.uw.edu.pl/en/"><img src="https://static.igem.org/mediawiki/2008/6/67/Uw.gif" width="100" height="99" border="0" /></a>
     <td align="center" valign="bottom"><a href="http://www.uw.edu.pl/en/"><img src="https://static.igem.org/mediawiki/2008/6/67/Uw.gif" width="100" height="99" border="0" /></a>
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     <a href="http://www.uw.edu.pl/en/"><h3>University of Warsaw</h3> </a></td>
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     <a href="http://www.uw.edu.pl/en/"><h4>University of Warsaw</h4> </a></td>
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     <td align="center" valign="bottom"><a href="http://www.fundacjauv.org.pl/"><img src="https://static.igem.org/mediawiki/2008/4/4d/Fundacja_uv-1.gif" width="160" height="65" border="0" /></a>
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     <a href="http://www.fundacjauv.org.pl/"><h3>The Universitatis Varsoviensis Fund </h3></a></td>
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<a href="http://www.biol.uw.edu.pl/_2008eng/"><img src="https://static.igem.org/mediawiki/2008/f/f3/Faculty-of-Biology.gif" width="57" height="75" border="0" /></a>
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     <a href="http://www.biol.uw.edu.pl/_2008eng/"><h4>Faculty of Biology, University of Warsaw </h4></a>    
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     <td align="center" valign="bottom"><a href="http://www.biol.uw.edu.pl/_2008eng/"><img src="https://static.igem.org/mediawiki/2008/f/f3/Faculty-of-Biology.gif" width="57" height="75" border="0" /></a>
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     <td align="center" valign="bottom"><a href="http://www.fundacjauv.org.pl/"><img src="https://static.igem.org/mediawiki/2008/4/4d/Fundacja_uv-1.gif" width="160" height="65" border="0" /></a>
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     <a href="http://www.biol.uw.edu.pl/_2008eng/"><h3>Faculty of Biology, University of Warsaw </h3></a>     </td>
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     <a href="http://www.fundacjauv.org.pl/"><h4>The Universitatis Varsoviensis Foundation </h4></a></td>
     <td align="center" valign="bottom"><a href="http://www.fnp.org.pl/ang/index.html"><img src="https://static.igem.org/mediawiki/2008/c/c9/LogoFNP1wers.gif" width="221" height="75" border="0" /></a>
     <td align="center" valign="bottom"><a href="http://www.fnp.org.pl/ang/index.html"><img src="https://static.igem.org/mediawiki/2008/c/c9/LogoFNP1wers.gif" width="221" height="75" border="0" /></a>
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     <a href="http://www.fnp.org.pl/ang/index.html"><h3>Foundation for Polish Science </h3></a></td>
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     <a href="http://www.fnp.org.pl/ang/index.html"><h4>Foundation for Polish Science </h4></a></td>
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     <td align="center" valign="bottom"><a href="http://www.biol.uw.edu.pl/_2008eng/index_2501.php?a_2501=529&amp;b_2501=5"><h3>Department of Bacterial Genetics </h3></a></td>
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     <td align="center" valign="bottom"><a href="http://www.biol.uw.edu.pl/_2008eng/index_2501.php?a_2501=526&amp;b_2501=5"><h3>Department of Virology</h3> </a></td>
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<a href="http://www.fuw.pl"><h4>Warsaw University Foundation</h4></a>
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<a href="http://www.iimcb.gov.pl/zylicz_lab.php"><h4>Department of Molecular Biology, International Institute of Molecular and Cell Biology</h4></a>
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<p>Units belonging to the <a href="http://www.biol.uw.edu.pl/_2008eng/">Faculty of Biology, University of Warsaw</a>, who kindly provided access to laboratory space and equipment:</p>
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     <td align="center" valign="bottom"><a href="http://www.biol.uw.edu.pl/_2008eng/index_2501.php?a_2501=541&amp;b_2501=5"><h3>Department of Plant Molecular Biology </h3></a></td>
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     <td align="center" valign="bottom"><a href="http://www.biol.uw.edu.pl/_2008eng/index_2501.php?a_2501=541&amp;b_2501=5"><h4>Department of Plant Molecular Biology </h4></a></td>
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     <td align="center" valign="bottom"><a href="http://www.biol.uw.edu.pl/_2008eng/index_2501.php?a_2501=534&amp;b_2501=5"><h3>Institute of Genetics and Biotechnology</h3></a> </td>
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     <td align="center" valign="bottom"><a href="http://www.biol.uw.edu.pl/_2008eng/index_2501.php?a_2501=526&amp;b_2501=5"><h4>Department of Virology</h4> </a> </td>
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     <td align="center" valign="bottom"<a href="http://www.iimcb.gov.pl/zylicz_lab.php"><h3>Department of Molecular Biology, IIMCB</h3></a></td>
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<a href="http://www.biol.uw.edu.pl/_2008eng/index_2501.php?a_2501=529&amp;b_2501=5"><h4>Department of Bacterial Genetics </h4></a>
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<td align="center" valign="bottom"><a href="http://www.biol.uw.edu.pl/_2008eng/index_2501.php?a_2501=534&amp;b_2501=5"><h4>Institute of Genetics and Biotechnology</h4></a></td>
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Latest revision as of 21:27, 29 October 2008

Gallery Bricks Notebook Team Project Home

A novel system for generation and screening for new interactors targeted against any bait

  • maximization of interaction between given bait and randomly generated protein by mutating sequence of the latter
  • interactor presentation on bacterial surface
  • selection of best bait interactor


Institutions whom we would like to thank for financial and technical support:

University of Warsaw

Faculty of Biology, University of Warsaw

The Universitatis Varsoviensis Foundation

Foundation for Polish Science

Warsaw University Foundation

Department of Molecular Biology, International Institute of Molecular and Cell Biology

Units belonging to the Faculty of Biology, University of Warsaw, who kindly provided access to laboratory space and equipment:

Department of Plant Molecular Biology

Department of Virology

Department of Bacterial Genetics

Institute of Genetics and Biotechnology