Team:ETH Zurich

From 2008.igem.org

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== The Team ==
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    <li>[https://2008.igem.org/User:juliasl Julia Slipantschuk]</li>
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    <li>[https://2008.igem.org/User:sgiese Sebastian Giese]</li>
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    <li>[https://2008.igem.org/User:Nico Nico Hensgens]</li>
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    <li>[https://2008.igem.org/User:ruby Rebecca Herbst]</li>
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    <li>[https://2008.igem.org/User:User:rbyun Reine Byun]</li>
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    <li>[https://2008.igem.org/User:Georg Georg Ofenbeck]</li>
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<strong>Graduate Students</strong>
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    <li>[https://2008.igem.org/User:snev Sven Lucas Dietz]</li>
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    <li>[https://2008.igem.org/User:Luca.Gerosa Luca Gerosa]</li>
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    <li> [http://www.biol.ethz.ch/IMB/groups/ban_group/members/jrabl Julius Rabl]</li>
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Advisors
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    <li>[http://www.ipe.ethz.ch/laboratories/bpl/people/panke Sven Panke]</li>
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    <li>[http://www.ipe.ethz.ch/laboratories/bpl/people/meyer Andreas J&ouml;rg Meyer]</li>
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    <li>[http://www.csb.ethz.ch/people/joergs J&ouml;rg Stelling]</li>
== Site Map  ==
== Site Map  ==
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Revision as of 23:34, 26 October 2008



Project Abstract

'Random walks towards the minimal genome'

"This year's ETH Zurich project tackles a fundamental problem of synthetic biology: the minimal genome. Exploring the minimal set of genes that is able to support life is not only a question of significant biological interest, it is also a crucial step towards the implementation of orthogonal functionalities into a rationally designed complex biological system. An organism carrying a minimal genome would provide a simple chassis for biological engineering. We attempted to exploit the power of accelerated evolution for a genome reduction strategy. Our approach is based on an iterative cycle of genome reduction and strain selection. We propose a novel method to randomly delete chromosomal DNA fragments by controlled expression of restriction enzymes and ligases in vivo. Furthermore we develop a chemostat-based selective condition to select for cells with a smaller genome size by constraining nucleotide availability. Computationally, we analyze the genome for the optimal restriction enzyme, and perform flux balance analysis on a genome scale model to predict growth of reduced genome strains. Finally, we simulate the restriction enzyme expression and the progression of selection."

The Team

  • Julia Slipantschuk</li>
  • Sebastian Giese</li>
  • Nico Hensgens</li>
  • Rebecca Herbst</li>
  • Reine Byun</li>
  • Georg Ofenbeck</li> Graduate Students
  • Sven Lucas Dietz</li>
  • Luca Gerosa</li>
  • [http://www.biol.ethz.ch/IMB/groups/ban_group/members/jrabl Julius Rabl]</li> Advisors
  • [http://www.ipe.ethz.ch/laboratories/bpl/people/panke Sven Panke]</li>
  • [http://www.ipe.ethz.ch/laboratories/bpl/people/meyer Andreas Jörg Meyer]</li>
  • [http://www.csb.ethz.ch/people/joergs Jörg Stelling]</li>

    Site Map

    Site Map of the ETHZ Side
    Home Team Project Wetlab Modeling Tools
    Overview Overview Overview Overview Overview Wiki Templates
    ETH Zuerich Members Motivation Genome Reduction Framework Automated Wiki
    Credits Pictures Background Chemostat Selection Genome Static Analysis
    Applications Switch Circuit Genome Scale Model
    Conclusions Materials & Methods Chemostat Selection
    Medal Relevant Switch Circuit
    Download