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Team:Freiburg/Project
From 2008.igem.org
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{{Freiburg2008_Main| | {{Freiburg2008_Main| | ||
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| - | + | '''Abstract:'''<br> | |
| + | This year´s main project is the attempt to create an "artificial receptor-system", featuring extra- and intracellular modules as well as suitable transmembrane regions. | ||
| + | The intracellular domaine of our receptor-device is build by halves of split reporter-proteins that can reassemble and will then produce readable output, e. g. fluorescence. | ||
| + | Each one of these protein-halves is connected to its extracellular domaine by a single-span transmembrane-helix. | ||
| + | The extracellular or detecting domaine consists of a protein or peptide with the ability to bind a certain molecule.<br> | ||
| + | Now, if a system with two matching receptors is presented these molecules in a strict, pairwise spacial arrangement, the receptor-devices are brought together, | ||
| + | the split reporter-protein reassembles inside the cell and the output can be detected. | ||
| + | We employ so-called "Origami-DNA" to create the exactly defined molecule-patterns that are needed to activate our receptors. | ||
| + | [[Modular Synthetic Receptor System|Project Report]] | ||
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}} | }} | ||
Revision as of 21:50, 29 September 2008
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Project Report |
Abstract: |
