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Team:EPF-Lausanne/Project
From 2008.igem.org
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Two-signals integrating cellular system
Overall project
The idea of the project is to build a cellular system that allows the cell to respond in different ways according to the received signal, emitted by the neighbouring cells. It will then emit its proper signal that will be transfered to the following cells.
Biomedical application
We may be able to aplly this idea to automated system of drug producing for personal medicine. In such a system, you just put a sample of blood in the first column of a microfluidic chip, then engineered cells in the wells detect some solutes, antibodies, and so on, and produce a signal given what they detect. Then the signal is integrated along the chip and when it reaches the last column, the engineered cell put in the wells are able to produce drugs responding to diseases detected along the chip.
As you would certainly suppose, we will not be able to engineer all the cell types to aim this goal in one summer, but we want through our project to make a few first steps to make such a system feasable in the future.
Project Details
The idea of the project is to build a system which uses two different quorum sensing sets of molecules that make the cell able to integrate three different levels of signal, and emit a different response, by producing a given fluorescent protein and a quorum sensing molecule.
