Team:Freiburg/Modeling
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Revision as of 12:30, 27 October 2008
Modeling |
_modeling
IntroductionThe dimerization of the extracellular receptor domains is a important necessity for the functionality of our modular receptor system. Presenting the system a stimulus in the form of spatial arranged ligands, the extracellular domains dimerize, thus the corresponding intracellular parts such as the split lactamase halves or split fluorescent proteins complement to measureable output. To analyse the theoretical functionality due to dimerization, first two receptor dimerization models (one T cell receptor model and one general receptor model) are introduced and discussed and then a proper model for the modular receptor system is constructed.
T cell receptor dimerization model I
Extracellular signalingA simplified pathway shows the extracellular sequence of TCR activation. After the NIP binding two complexes come together and form a dimer which then leads to activaton of the TCR and further intracellular signaling and T cell activation. |