Team:Paris/Analysis/Construction2
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- | <TD COLSPAN=2> | + | <TD COLSPAN=2> In order to model the quorum sensing dynamics, we consider that: </TD> |
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- | <TD COLSPAN=2> | + | <TD COLSPAN=2> 1) Inside a cell, the HSL concentration depends on: </TD> |
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+ | <TD COLSPAN=2>[[Image:final_HSL.png|center|400px|]]</TD> | ||
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+ | <TD COLSPAN=2> 2) Outside the cells, the HSL concentration is given by: </TD> | ||
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+ | <TD COLSPAN=2>[[Image:HSLext.png|center|500px]] </TD> | ||
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+ | <TD COLSPAN=2> that is equivalent to: </TD> | ||
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+ | <TD COLSPAN=2>[[Image:HSLext2.png|550px]] </TD> | ||
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+ | <TD COLSPAN=2>where [[Image:Hsl_average.png|120px]] and [[Image:cell_number_volume.png|80px]]</TD> | ||
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+ | <TD COLSPAN=2> 3) The activation of ''envZ'' depends of the concentration of HSL according to: </TD> | ||
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+ | <TD COLSPAN=2>[[Image:Final_EnvZ.png|center|400px]] </TD> | ||
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Revision as of 18:54, 27 October 2008
Model Construction
MotivationWe are interested to understand the factors that account for an oscillating behaviour at population level. We build two models to study systems that are equipated with quorum sensing capabilities but that relay on different designs principles. The proposed models are:
Both the modular and the all-in-one models describe events that happend not only at the cellular level (as in the core system) but also at the population level due to interactions needed bettwen a cell and its environment during quorum sensing. In the following sections, we first describe the population modeling (the common part amoung our two proposed models) to then focus our attention to the characteristics that are exclusive to each of the modeling alternatives.
Population Modeling
Kinetics
Parameters Searchmanly from literature but also from S0 analysis.
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