Team:Paris/Analysis/Construction2
From 2008.igem.org
(→Kinetics) |
(→Motivation) |
||
Line 5: | Line 5: | ||
We are interested to understand the factors that account for an oscillating behaviour at population level. We build two models to study systems that are equipated with quorum sensing capabilities but that relay on different designs principles. The proposed models are: | We are interested to understand the factors that account for an oscillating behaviour at population level. We build two models to study systems that are equipated with quorum sensing capabilities but that relay on different designs principles. The proposed models are: | ||
- | *In the one model, we use a modular design. We consider that the core system is one of the modules of the system. In adittion, the other module is an two gene oscillator system presented in | + | *In the one model, we use a modular design. We consider that the core system is one of the modules of the system. In adittion, the other module is an two gene oscillator system presented in [[Team:Paris/Modeling/BOB#Bibliography|[Garcia-Ojalvo]]] that accounts for quorum sensing. |
*In the other model, we rewire the architecture of the core system to have the desired functionality of the system in a single circuit. | *In the other model, we rewire the architecture of the core system to have the desired functionality of the system in a single circuit. | ||
Line 12: | Line 12: | ||
In the following sections, we first describe the population modeling (the common part amoung our two proposed models) to then focus our attention to the characteristics that are exclusive to each of the modeling alternatives. | In the following sections, we first describe the population modeling (the common part amoung our two proposed models) to then focus our attention to the characteristics that are exclusive to each of the modeling alternatives. | ||
- | |||
== Population Modeling == | == Population Modeling == |
Revision as of 19:05, 27 October 2008
Model Construction
MotivationWe are interested to understand the factors that account for an oscillating behaviour at population level. We build two models to study systems that are equipated with quorum sensing capabilities but that relay on different designs principles. The proposed models are:
Both the modular and the all-in-one models describe events that happend not only at the cellular level (as in the core system) but also at the population level due to interactions needed bettwen a cell and its environment during quorum sensing. In the following sections, we first describe the population modeling (the common part amoung our two proposed models) to then focus our attention to the characteristics that are exclusive to each of the modeling alternatives. Population Modeling
Kinetics
Parameters Searchmanly from literature but also from S0 analysis.
|