Creating an oscillatory system

Already existing genetic oscillators and their limits

Designing a simple genetic network that presents an oscillatory behavior is one of the first challenge synthetic biology overcame. More or less successfully. We can count more than ten synthetic genetic oscillators that have varied period and mechanisms. Raúl GUANTES and Juan F. POYATOS (2006) studied the most simple oscillators composed of two elements while Michael B. ELOWITZ and Stanislas LEIBLER (2000) designed the more complex "repressilator" (Table 1), to quote only the best known.

Two examples of genetic oscillators. A : a simple oscillator composed of two elements. B : the repressilator. (Legend : Green arrow : Activation. Red blunt arrow : Inhibition)

Design of our genetic oscillator : The Feed Forward Loop

Limits of our network