Las signaling system
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Las/Rhl cell signaling system
Las System
Signal Molecule: An AHL called PAI-1 (N-3-oxododecanoyl-l-hsl)(3-oxo-C12-hsl)
Bacterial species: Pseudomonas aeruginosa gram(-) possibly E.coli (see article 3)
Receiver protein: LasR
Effect of binding: TXN activation of virulence genes, lasA, lasB, apr, toxR
Synthase: LasI enzyme
Target Genes: lasI, lasA, lasB, apr, toxR
Regulation: unknown
References
"Roles of Pseudomonas aeruginosa las and rhl quorum-sensing systems in control of elastase and rhamnolipid biosynthesis genes"
JP Pearson, EC Pesci and BH Iglewski [1]
"Regulation of Pseudomonas Quinolone Signal Synthesis in Pseudomonas aeruginosa"
Dana S. Wade, M. Worth Calfee, Edson R. Rocha, Elizabeth A. Ling, Elana Engstrom, James P. Coleman, and Everett C. Pesci 2
Posttranscriptional Control of Quorum-Sensing-Dependent Virulence Genes by DksA in Pseudomonas aeruginosa
Florence Jude,Thilo Köhler,Pavel Branny,Karl Perron,Matthias P. Mayer,Rachel Comte, and Christian van Delden 3
Pending: [2]
Rhl System
Signal Molecule: An AHL called PAI-2, Plasminogen activator inhibitor-2, N-butanoyl-homoserine lactone (C4HSL)
Bacterial species: Pseudomonas aeruginosa, gram(-)
Receiver Protein: Rhl R
Effect of Binding: activation of Rhamnosyl Transferase, then making RL (rhamnolipid)
Synthase: RhlA and RhlB
Target Genes: pqsABCDE and phnAB
Regulation: unknown
References
background information on Las and Rhl