NYMU-Taipei/Project/Phosphate/Phosphate-related Medical Syndromes

From 2008.igem.org

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  • When the phosphate level in blood exceeds 6.5 mg/dL, a patient kidney failure has a high risk of death
  • A high serum concentration of phosphate (pi) is clearly related to pruritus and hyperparathyroidism, both manifestations of the uremic syndrome
  • Phosphorus excess also inhibits 1 alpha-hydroxylase and hence the production of calcitriol, the active vitamin D metabolite
  • Phosphorus retention also alters polyamine metabolism by causing decreases in intestinal function and proliferation of intestinal villi