NYMU-Taipei/Project/Phosphate/Phosphate-related Medical Syndromes
From 2008.igem.org
- When the phosphate level in blood exceeds 6.5 mg/dL, a patient kidney failure has a high risk of death
- A high serum concentration of phosphate (pi) is clearly related to pruritus and hyperparathyroidism, both manifestations of the uremic syndrome
- Phosphorus excess also inhibits 1 alpha-hydroxylase and hence the production of calcitriol, the active vitamin D metabolite
- Phosphorus retention also alters polyamine metabolism by causing decreases in intestinal function and proliferation of intestinal villi