From 2008.igem.org
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| | ==Todo== | | ==Todo== |
| - | * Continue the previous model | + | * On the previous model |
| - | ** Synchronyzation | + | ** add cells |
| - | ** Estimation of the FIFO processes | + | ** have a population that changes over time |
| - | ** Stochastic modeling (Gilespie) | + | ** Parameters robustness (threshold, Pa) (screening) |
| - | *Test the robustness | + | ** Gillespie : rebuild the model with this new approach // noise |
| - | **repressilator | + | ** Quantification of FIFO (see Yann) |
| - | ** comparison | + | ** Quantification period (influent parameters...) |
| - | *Enhance the system | + | |
| - | **Better FIFO behaviour | + | * Other ideas |
| - | **Other interactions to increase the robustness | + | ** biocham : comparison with adapted repressilator |
| | + | ** system to add "random" links for model optimisation (quantification of quality : see that oscillation FIFO and synchronization still occur) |
| | + | ** change place of tetR (on flgA...) |
| | + | ** see mgs (gillespie or spatialization) |
| | + | ** highly rigorous model with mRNA and ON/OFF |
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| | ==Bonus ideas== | | ==Bonus ideas== |
Revision as of 17:49, 8 August 2008
Calendar
July
- 07/31 - Have a full bibliography ⇒ DONE
August
- 06/07 - First model of the FIFO temporal order, of the backward control inducing the oscillations ⇒ DONE
- 08/07 - Model the synchronization between cells, using Biocham
- 08/15 - Summary about the ODE method, Space introduction into models (AC, Delaunay)
- 08/22 - Feedback: list missing things (parameters), Optimization, Robustness analysis
September
- 09/22- Checkpoint meeting
October
- 10/15 - Scheduled wiki ending (2 weeks before the real ending to finish details)
- 10/31 - Official wiki ending (date to be checked)
Todo
- On the previous model
- add cells
- have a population that changes over time
- Parameters robustness (threshold, Pa) (screening)
- Gillespie : rebuild the model with this new approach // noise
- Quantification of FIFO (see Yann)
- Quantification period (influent parameters...)
- Other ideas
- biocham : comparison with adapted repressilator
- system to add "random" links for model optimisation (quantification of quality : see that oscillation FIFO and synchronization still occur)
- change place of tetR (on flgA...)
- see mgs (gillespie or spatialization)
- highly rigorous model with mRNA and ON/OFF
Bonus ideas
- optimization of the links in a bio process
- new way to see modeling (stochastic / ON&OFF + mRNA...)
- new way to model noise
- using the noise?
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