Team:Paris/Network analysis and design/System improvements

Name	Description	Evaluation	Links
Core system	Figure core system		Liks core system
Modular system	Figure modular system	File:Orgstar.GIFFile:Orgstar.GIF	Links Garcia-Ojalvo
Resulting system	Figure resulting system	File:Orgstar.GIFFile:Orgstar.GIFFile:Orgstar.GIF	Links resulting
Synchronized oscillations should be given by S2.

Core system does not oscillate. How can we enhance it?

We need a 'delay' so we can:

1 add more genes to the circuit

2 use quorum sensing (qs)

we chose quorum sensing that can allowed both 'delay' and population synchonization. two ways to add it:

• S4: Inspired from Garcia-Ojalvo: oscillating repressilator + oscillating qs module = synchronized oscillations

• S2: it amounts to replace single interaction by more complex interactions: should create delay

we analyze both systems for their capacity to generate oscillations. S2 seems more promising. Thus we further analize S2 for its capacity to generate synchrionized oscillations.