Team:Brown

From 2008.igem.org

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     <td>Around the world, contamination of drinking water is an immense  problem that is difficult and expensive to detect with current  technology. As such, many Third World countries are unable to  effectively diagnose the problem across the millions of water supply  sources that exist.  There is a need for an economically feasible, transportable, and  user-friendly detection system for water contamination that can  reliably be used in the field. </p>
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     <td><p>Brown iGEM's 2008 Team focused on designing a novel electrical reporting system that could be used as a method of toxin detection, particularly in third-world countries, where water pollution is a prevalent problem. </p>
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    <p>Our work focuses on designing and implementing a novel  biosensor that reports information back in a simple electric signal. Our biosensor will have the ability to detect the presence of certain inducers (for example a water contaminant or toxin), and report that information back via a change in the conductance of the bacterial solution. An inducer specific promoter transcribes and leads to the subsequent translation of a “Lysis Gene Cassette.” Lysis of the  bacteria results in the release of the bulk intracellular ionic content  into the surrounding media, causing the solution’s conductivity to  increase, thereby indicating the presence of the inducer. </p></td>
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      <p>Through the use of a lysis gene cassette bound to an inducible promoter in E.coli bacteria, the biosensor will have the ability to detect the presence of a certain substance (for example a water toxin)and report that information back via a change in the conductance of the bacterial solution. Through the use of minimal biological machinery and a versatile construct, our system can provide for a sensitive and compact system for substance analysis. </p>
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      <p>See the video for a team &amp; project overview!</p>
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       <object style="margin:0px" width="425" height="355"><param name="movie" value="http://static.slideshare.net/swf/ssplayer2.swf?doc=resistance-4-updates-1225059052545214-8&rel=0&stripped_title=brown-igem-toxipop-presentation-presentation" /><param name="allowFullScreen" value="true"/><param name="allowScriptAccess" value="always"/><embed src="http://static.slideshare.net/swf/ssplayer2.swf?doc=resistance-4-updates-1225059052545214-8&rel=0&stripped_title=brown-igem-toxipop-presentation-presentation" type="application/x-shockwave-flash" allowscriptaccess="always" allowfullscreen="true" width="425" height="355"></embed></object>
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       <p><img src="https://static.igem.org/mediawiki/2008/f/f7/Brown_igem_logo2.png" width="337" height="267" border="0" align="center"/></p>
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      <div style="font-size:11px;font-family:tahoma,arial;height:26px;padding-top:2px;">View SlideShare <a style="text-decoration:underline;" href="http://www.slideshare.net/neilparikh/brown-igem-toxipop-presentation-presentation?type=powerpoint" title="View Brown iGEM Toxipop Presentation on SlideShare">presentation</a>.</div>
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    <p>&nbsp;</p>
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    <td><embed src="http://blip.tv/play/AdX1EpDPGQ" type="application/x-shockwave-flash" width="510" height="408" allowscriptaccess="always" allowfullscreen="true"></embed> </td>
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Latest revision as of 05:35, 28 October 2008



Brownwelcome.png

Brown iGEM's 2008 Team focused on designing a novel electrical reporting system that could be used as a method of toxin detection, particularly in third-world countries, where water pollution is a prevalent problem.

Through the use of a lysis gene cassette bound to an inducible promoter in E.coli bacteria, the biosensor will have the ability to detect the presence of a certain substance (for example a water toxin)and report that information back via a change in the conductance of the bacterial solution. Through the use of minimal biological machinery and a versatile construct, our system can provide for a sensitive and compact system for substance analysis.

See the video for a team & project overview!

 

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