Team:Alberta NINT

From 2008.igem.org

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             <td width="599">NINT iGEM <strong><br />
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             <td width="599" height = "200"></br>NINT iGEM <strong></br></br>
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             Logi - col[i]</strong><span class="style6"><br />  
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             A gateway to things both logical and colilogical,  coli-licious, coli-ish, coli-ly, small living  stuff. </span><br /></td>
             A gateway to things both logical and colilogical,  coli-licious, coli-ish, coli-ly, small living  stuff. </span><br /></td>
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             <td width="251"><img src="https://static.igem.org/mediawiki/2008/e/e3/NINTiGEM_Logicoli.jpg" width="251" height="163" /></td>
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                 <td width="598" bgcolor="#990000" align="left"><span class="style7">Home Page Content</span></td>
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                 <td width="598" bgcolor="#990000" align="left"><span class="style7">Project Summary</span></td>
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                     <span class="style9">Home page content is so great and interesting
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                     <span class="style9"><blockquote>Two major hurdles facing the development of complex genetic logic circuits are device connectibility and device extensibility. Connectibility refers to the ability to connect the output of one device to the input of another device, while extensibility refers to the dual abilities to rationally design new devices and to combine multiple devices in one organism. Our project uses terminator/attenuator (T/A) hairpin sequences (gates) to control transcription and anti-sense RNA as input/output signals to/from the devices. We call this approach Terminator/Attenuator anti-sense Logic (T/AasL – pronounced “tossle”). It solves the connectibility problems of common protein-based approaches because the anti-sense output of one device is used to disrupt formation of T/A hairpin structures of downstream devices, thus activating them. In addition, because RNA secondary structures can be rationally designed (using our m-fold derived analysis program) we can readily construct a large family of devices with minimal cross-talk for inclusion in a single cell.               </blockquote></p>
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                  <p class="style9">More text that has absolutely no meaning but I need it to fill up space here so I keep writing it over and over and now it suddenly actually has some sort of meaning. More text that has absolutely no meaning but I need it to fill up space here so I keep writing it over and over and now it suddenly actually has some sort of meaning.                  More text that has absolutely no meaning but I need it to fill up space here so I keep writing it over and over and now it suddenly actually has some sort of meaning.                  </p>
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                  <p class="style9">More text that has absolutely no meaning but I need it to fill up space here so I keep writing it over and over and now it suddenly actually has some sort of meaning. More text that has absolutely no meaning but I need it to fill up space here so I keep writing it over and over and now it suddenly actually has some sort of meaning.                 More text that has absolutely no meaning but I need it to fill up space here so I keep writing it over and over and now it suddenly actually has some sort of meaning.                  </p>
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Revision as of 17:33, 4 October 2008

Untitled Document


NINT iGEM

Logi - col[i]


A gateway to things both logical and colilogical, coli-licious, coli-ish, coli-ly, small living stuff.
HOME
The Team
The Project
Lab Protocols
Bits And Pieces
Modeling
Notebook
Project Summary


Two major hurdles facing the development of complex genetic logic circuits are device connectibility and device extensibility. Connectibility refers to the ability to connect the output of one device to the input of another device, while extensibility refers to the dual abilities to rationally design new devices and to combine multiple devices in one organism. Our project uses terminator/attenuator (T/A) hairpin sequences (gates) to control transcription and anti-sense RNA as input/output signals to/from the devices. We call this approach Terminator/Attenuator anti-sense Logic (T/AasL – pronounced “tossle”). It solves the connectibility problems of common protein-based approaches because the anti-sense output of one device is used to disrupt formation of T/A hairpin structures of downstream devices, thus activating them. In addition, because RNA secondary structures can be rationally designed (using our m-fold derived analysis program) we can readily construct a large family of devices with minimal cross-talk for inclusion in a single cell.

Sponsors
  • Alberta Ingenuity
  • Department of Medical Microbiology and Immunology (University of Alberta)
  • Department of Cell Biology (University of Alberta)
  • National Institute for Nanotechnology

 

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