Team:Paris/Network analysis and design/System improvements

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Revision as of 04:45, 26 October 2008

System Improvements

Synchronized oscillations should be given by S2.
Name	Description	Evaluation	Links
Core system	Figure core system	File:Equilibrium.jpg	Links core system
Modular system	Figure modular system	File:Damped.jpg	Links Garcia-Ojalvo
Resulting system	Figure resulting system	File:Oscillating.jpg	Links resulting

Core system does not oscillate. How can we enhance it?

We need a 'delay' so we can:

1 add more genes to the circuit

2 use quorum sensing (qs)

we chose quorum sensing that can allowed both 'delay' and population synchonization. two ways to add it:

S4: Inspired from Garcia-Ojalvo: oscillating repressilator + oscillating qs module = synchronized oscillations

S2: it amounts to replace single interaction by more complex interactions: should create delay

we analyze both systems for their capacity to generate oscillations.

S2 seems more promising.

Thus we further analize S2 for its capacity to generate synchrionized oscillations (using different initial concentrations and cell populations variability).

@@ Line 43: / Line 43: @@
 *S2: it amounts to replace single interaction by more complex interactions: should create delay
-we analyze both systems for their capacity to generate oscillations. S2 seems more promising. Thus we further analize S2 for its capacity to generate ''synchrionized'' oscillations.
+we analyze both systems for their capacity to generate oscillations.
+S2 seems more promising.
+Thus we further analize S2 for its capacity to generate ''synchrionized'' oscillations (using different initial concentrations and cell populations variability).
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