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Team:Rice University
From 2008.igem.org
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== '''BioBeer: Producing Resveratrol During Beer Fermentation''' == | == '''BioBeer: Producing Resveratrol During Beer Fermentation''' == | ||
| - | + | [[Image:trans-resveratrol.jpg|right|frame|none|trans-Resveratrol]] | |
| - | === '''Resveratrol''' === | + | === '''Resveratrol''' === |
:* First identified as the active component in ''C. quinquangulata'' (cinnamon) extract responsible for anti-inflammatory properties. <BR> | :* First identified as the active component in ''C. quinquangulata'' (cinnamon) extract responsible for anti-inflammatory properties. <BR> | ||
:* Normally used as a defense mechanism in plants in response to fungal pathogens and UV irradiation. <BR> | :* Normally used as a defense mechanism in plants in response to fungal pathogens and UV irradiation. <BR> | ||
:* Main source in human diet is red wine, but significant amounts are also found in grape juice, peanuts, cranberry juice, and other sources. | :* Main source in human diet is red wine, but significant amounts are also found in grape juice, peanuts, cranberry juice, and other sources. | ||
:* There is a tremendous interest in the potential of resveratrol for various health benefits. A PubMed search for 'resveratrol' returns '''2,470''' scientific articles. | :* There is a tremendous interest in the potential of resveratrol for various health benefits. A PubMed search for 'resveratrol' returns '''2,470''' scientific articles. | ||
| - | + | <BR><BR> | |
| - | + | ||
| + | [[Image:RSV-health.jpg|left|thumb|300px|Resveratrol has been shown to provide a wealth of health benefits.]] | ||
=== '''Health Benefits''' === | === '''Health Benefits''' === | ||
| - | + | ::::::::::::::* Improved cardiovascular function | |
| - | :* Improved cardiovascular function | + | ::::::::::::::* Increased insulin sensitivity |
| - | :* Increased insulin sensitivity | + | ::::::::::::::* Maintenance of neural pathways |
| - | :* Maintenance of neural pathways | + | ::::::::::::::* Inhibition of carcinogenesis |
| - | :* Inhibition of carcinogenesis | + | |
| - | <BR><BR> | + | |
| + | <BR><BR><BR><BR><BR><BR><BR> | ||
| + | <BR><BR><BR><BR><BR> | ||
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[[Image:winetobeer.jpg|right]] <BR><BR><BR><BR><BR> | [[Image:winetobeer.jpg|right]] <BR><BR><BR><BR><BR> | ||
[[Image:brewing.jpg|left]] | [[Image:brewing.jpg|left]] | ||
Revision as of 20:22, 26 October 2008
Contents |
Welcome to Rice University's 2008 iGEM wiki page.
Our project for this year is BIOBEER, where we are genetically engineering the biosynthetic pathway for resveratrol production into a brewing yeast strain. Resveratrol has been shown to have a plethora of health benefits, including anti-cancer and anti-viral activity, cardio- and neuro-protective effects, modulation of diabetes, and anti-aging effects. Although research has been done previously to produce resveratrol in various organisms, no one to date has developed a yeast strain able to synthesize resveratrol in a de novo manner. We are going one step further, characterizing resveratrol production during anaerobic fermentation with the intent of creating a beer that contains all the health benefits of wine. Get ready for resveratrol in a fizzy ready-to-consume beverage!
BioBeer: Producing Resveratrol During Beer Fermentation
Resveratrol
- First identified as the active component in C. quinquangulata (cinnamon) extract responsible for anti-inflammatory properties.
- Normally used as a defense mechanism in plants in response to fungal pathogens and UV irradiation.
- Main source in human diet is red wine, but significant amounts are also found in grape juice, peanuts, cranberry juice, and other sources.
- There is a tremendous interest in the potential of resveratrol for various health benefits. A PubMed search for 'resveratrol' returns 2,470 scientific articles.
- First identified as the active component in C. quinquangulata (cinnamon) extract responsible for anti-inflammatory properties.
Health Benefits
- Improved cardiovascular function
- Increased insulin sensitivity
- Maintenance of neural pathways
- Inhibition of carcinogenesis
Why resveratrol in beer?
-Beer made up 85.8% of all alcoholic beverage consumption (in total volume) in 2005.
-->Annual per capita consumption of Beer (2005) = ~20 gallons
-->Annual per capita consumption of Wine (2005) = ~2.5 gallons
-If resveratrol can be produced during fermentation, it provides an additional health benefit at no additional cost.
-->The resveratrol is produced in a ready-to-consume format!
-->Dark and anaerobic conditions required for fermentation improve resveratrol stability.
The Rice 2008 Synthetic BiOWLogists
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