Ideas:
-Counting in module 2 (even and odd) 2nd option
-Mosaic rejected
-Singing bacteria. Researching
-Pong Researching
-Balance between populations 2nd Option
-Counting days rejected
^sign-sensitive delay
Pong- Research
Possibilities
* Bacteria motility.
The cell motility trigger a repellent in the closer cell population, along with a reporter, then it would move to the second cell population, which will share the roles.
Repellent -> weak organic acids such as formic, acetic acid, benzoic, and salicylic [works by decreasing intracellular pH]. Amino acids as leucine and valine, indol. Also alcohols, polyols, and heavy cations (Co and Ni).
The stimulus is detected by a membrane receptor (MCP methyl accepting chemotaxis proteins) TSR, Tar, Trg, Tap [These 4 described in E.coli].
The cascade of signaling is initialized when there is a conformational change induced by ligand, in the cytoplasmic side of the protein. This change is recognized by a complex formed by CheA-CheW. CheA is a kinase that is inhibited when ligand recognizes attractors and is activated when repellent is present. CheA donates its phosphate to CheY and CheB, CheY-P interacts with a complex that has a switch function at the flagelar base engine, this switch is responsible for the change between CW [clockwise] and CCW [counterclockwise]. Studied in S. thypimurium and E. coli.
We still face the problem of degrading the repellent [activator], and the noise accumulation.
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