The BacterioClock

Were you dreaming about a new way of thinking everyday life objects ? Be sure that this will come true, under the form of our BacterioClock ! A simple tube which contains the modified bacteria we have created will give you the time, directly coming from living organisms.

To achieve this innovative project, we have decided to rely on a genetic structure that allows a specific sequence of lighting (Firt In - First Out behaviour) to occur. The models designed have shown that simply adding a negative feedback from a lighting gene to the first activator will not yield oscillations ! Therefore, we have proposed to induce a necessary delay, through a synchronization process among the population, as represented below :

DEGAGER We hereby wish to present our ambitious BacteriO'Clock! Synthetic biology is a new science, so we have to chance to set the base of synthetic biology. Hence our motto : Innovation! Therefore, we put a lot of efforts in proposing an original approach while building our system and analysing it.
We shall present here our major results. Then we wished to show how we tried to meet iGEM goals : "Can simple biological systems be built from standard, interchangeable parts and operated in living cells? Or is biology just too complicated to be engineered in this way?".

Achievements

First of all, we intended to build a multipurpose system, that would be able to behave as a FIFO and oscillate. Up to now, we managed to build biologically a system that is to behave as a FIFO, and designed the oscillatory system. We also foresaw improvments that would enhance our system performances, among which introducing a synchronization application.

Our biological results up to now

Promote the open and transparent development of tools for engineering biology

We have worked under the constraint that the research we carried would not content ourselves with proposing solutions for our system only. We are proud to propose two major approaches in that direction.

• First of all, usually systems are designed biologically only. We stressed on the importance that a system behavior could be predicted with few data. Right after the overall system had been designed by the whole team, we built quickly a first model that would help us

1.prédire les comportements avec un minimum de données! and then use biological data to understand par ex shéma model->lab->model donner exemple FIFO
2.akaike

Enable the systematic engineering of biology

1.biobriks
2.caractérisation Hugo
3.conception de protocoles systématiques, trouver des infos qui ne soient pas propres a notre propre systeme volonté d'établir des protocoles, standardiser les processus ingénieriser/montrer que la bio n'est pas trop compliquée a ingénieriser

Construct a society that can productively apply biological technology
projet bioplastiques//productivité+ pour l'industrie

The team !

multidisciplinaire donc différentes cultures enrichissantes! undergrad 20 personnes en alternances dou organisation

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