Team:Illinois/Antibody GPCR Fusion

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Contents

Core Team Members

Dave Luedtke, Bobak Hadidi

  • Add yourself!

Project Abstract

G protein-coupled receptors, or GPCRs, are transmembrane receptors sensing extracellular objects on the scale of small molecules to large proteins. Yeast cells are known to utilize two GPCRs signal transduction pathways, one to detect the presence of glucose and the other to initiate mating. We hope to engineer these well-characterized pathways to produce a colorimetric change in the cell upon detecting a novel molecule-- some water-bourne pathogen. Methods may include protein fusion or directed evolution.

Meetings

Fri. June 13th we will meet on the first floor of Grainger by the computers.

To Research

  • Cell Wall Issue
  • Antibody Sequence
  • Cholera Toxin or possible target protein
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