NYMU-Taipei/Project/Phosphate/Phosphate-related Medical Syndromes

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  • When the phosphate level in blood exceeds 6.5 mg/dL, a patient kidney failure has a high risk of death
  • A high serum concentration of [http://en.wikipedia.org/wiki/Phosphate phosphate (pi)] is clearly related to pruritus and hyperparathyroidism, both manifestations of the uremic syndrome
  • Phosphorus excess also inhibits 1 alpha-hydroxylase and hence the production of [http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a682335.html calcitriol], the active vitamin D metabolite
  • Phosphorus retention also alters polyamine metabolism by causing decreases in intestinal function and proliferation of intestinal villi

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