Team:BrownTwo

From 2008.igem.org

(Difference between revisions)
(A Genetic Limiter Circuit in S. cerevisiae)
(A Genetic Limiter Circuit in S. cerevisiae)
 
(9 intermediate revisions not shown)
Line 2: Line 2:
==A Genetic Limiter Circuit in ''S. cerevisiae''==
==A Genetic Limiter Circuit in ''S. cerevisiae''==
-
<br>
+
 
-
Numerous disease states in multicellular organisms involve anomalous expression patterns of endogenous genes.  Tumor growth, associated with the overexpression of oncogenes, is one vexing example in which this occurs.  While extremes of gene expression can damage living systems, normal expression is necessary for healthy function.  We have designed a modular genetic circuit to limit the expression level of a gene of interest to a user-defined, tunable threshold.  The limiter network reacts to the transcription of an endogenous gene within each cell, entering a regulatory state only where and when the rate of transcription lies beyond an acceptable range of activity.  Along with its potential therapeutic utility, we offer our device as a foundational tool for researching gene expression in a eukaryotic model.
+
 
 +
[[image:Glyph.png|center|400px]]
 +
<br><p>
 +
We have designed a modular genetic circuit to limit the expression level of a gene of interest to a user-defined, tunable threshold.  The limiter network reacts to the transcription of an endogenous gene within each cell, entering a regulatory state only where and when the rate of transcription lies beyond an acceptable range of activity.  Along with its potential therapeutic utility, we offer our device as a foundational tool for researching gene expression in a eukaryotic model.
 +
</p>
 +
 
 +
 
 +
<center>'''''This page is best viewed with any browser but Internet Explorer.'''''
 +
</center>

Latest revision as of 00:42, 30 October 2008



A Genetic Limiter Circuit in S. cerevisiae

Glyph.png

We have designed a modular genetic circuit to limit the expression level of a gene of interest to a user-defined, tunable threshold. The limiter network reacts to the transcription of an endogenous gene within each cell, entering a regulatory state only where and when the rate of transcription lies beyond an acceptable range of activity. Along with its potential therapeutic utility, we offer our device as a foundational tool for researching gene expression in a eukaryotic model.


This page is best viewed with any browser but Internet Explorer.