"
Team:BrownTwo/Limiter/utility
From 2008.igem.org
(Difference between revisions)
(→References) |
|||
| Line 5: | Line 5: | ||
<p>Much as excessive signal levels can destroy a radio transmitter, excessive genetic expression can cause damage in living systems. While cells are usually well-equipped to modulate their own transcriptional behavior, an investigation into pathological gene expression indicates that many situations arise wherein the expected regulatory response fails. Our device is designed to augment endogenous gene regulatory pathways.</p> | <p>Much as excessive signal levels can destroy a radio transmitter, excessive genetic expression can cause damage in living systems. While cells are usually well-equipped to modulate their own transcriptional behavior, an investigation into pathological gene expression indicates that many situations arise wherein the expected regulatory response fails. Our device is designed to augment endogenous gene regulatory pathways.</p> | ||
| - | + | <!-- | |
<p>While one can surely identify numerous cases of abnormal gene expression in cellular systems, we turn our attention to one particular network related to a crucial decision in cell fate, apoptosis.</p> | <p>While one can surely identify numerous cases of abnormal gene expression in cellular systems, we turn our attention to one particular network related to a crucial decision in cell fate, apoptosis.</p> | ||
| Line 37: | Line 37: | ||
<br>2. Toledo and Wahl, Regulating the p53 pathway:in vitro hypotheses, in vivo veritas, ''Nature Reviews'' vol 6. 2006 | <br>2. Toledo and Wahl, Regulating the p53 pathway:in vitro hypotheses, in vivo veritas, ''Nature Reviews'' vol 6. 2006 | ||
<br>3. Vucic and Fairbrother, The Inhibitor of Apoptosis Proteins as Therapeutic Targets in Cancer, ''Clin Cancer Res.'' 2007;13(20) | <br>3. Vucic and Fairbrother, The Inhibitor of Apoptosis Proteins as Therapeutic Targets in Cancer, ''Clin Cancer Res.'' 2007;13(20) | ||
| + | |||
| + | --!> | ||
Latest revision as of 16:34, 8 November 2010
The utility of threshold limitationMuch as excessive signal levels can destroy a radio transmitter, excessive genetic expression can cause damage in living systems. While cells are usually well-equipped to modulate their own transcriptional behavior, an investigation into pathological gene expression indicates that many situations arise wherein the expected regulatory response fails. Our device is designed to augment endogenous gene regulatory pathways.
|
