Team:Paris/Analysis/Construction2
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We are interested to understand the factors that account for an oscillating behaviour at population level. We build two models to study systems that are equipated with quorum sensing capabilities but that relay on different designs principles. | We are interested to understand the factors that account for an oscillating behaviour at population level. We build two models to study systems that are equipated with quorum sensing capabilities but that relay on different designs principles. | ||
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+ | joint our quest for alternatives... | ||
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+ | <CENTER> | ||
+ | <TABLE WIDTH=90%> | ||
+ | <TR ALIGN=CENTER VALIGN=MIDDLE> | ||
+ | <TD></TD> | ||
+ | <TD COLSPAN=2 BGCOLOR="#649CD7"><B>Same environment </B></TD> | ||
+ | <TD></TD> | ||
+ | </TR> | ||
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+ | <TR ALIGN=CENTER VALIGN=MIDDLE> | ||
+ | <TD></TD> | ||
+ | <TD COLSPAN=2>[[Image:chemostat.png|center|300px]]</TD> | ||
+ | <TD></TD> | ||
+ | </TR> | ||
+ | |||
+ | <TR ALIGN=CENTER VALIGN=MIDDLE> | ||
+ | <TD></TD> | ||
+ | <TD COLSPAN=2 BGCOLOR="#649CD7"><B>Same starting point </B></TD> | ||
+ | <TD></TD> | ||
+ | </TR> | ||
+ | |||
+ | <TR ALIGN=CENTER VALIGN=MIDDLE> | ||
+ | <TD></TD> | ||
+ | <TD COLSPAN=2>[[Image:CoreSystem0.png|center|300px]] The core system</TD> | ||
+ | <TD></TD> | ||
+ | </TR> | ||
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+ | <TR ALIGN=CENTER VALIGN=MIDDLE> | ||
+ | <TD></TD> | ||
+ | <TD COLSPAN=2>[[Image:CoreSystemKeep3.png|center|300px]] We keep 3 interactions</TD> | ||
+ | <TD></TD> | ||
+ | </TR> | ||
+ | |||
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+ | <TR ALIGN=CENTER VALIGN=MIDDLE> | ||
+ | <TD></TD> | ||
+ | <TD COLSPAN=2 BGCOLOR="#649CD7"><B>Same quorum sensing mechanism </B></TD> | ||
+ | <TD></TD> | ||
+ | </TR> | ||
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+ | <TR ALIGN=CENTER VALIGN=MIDDLE> | ||
+ | <TD></TD> | ||
+ | <TD COLSPAN=2>[[Image:CoreSystemQS.png|center|300px]] lasI indirectly activates ''envZ'' via HSL</TD> | ||
+ | <TD></TD> | ||
+ | </TR> | ||
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+ | <TR ALIGN=CENTER VALIGN=MIDDLE> | ||
+ | <TD COLSPAN=2 BGCOLOR="#D4E2EF"><B>Alternative One</B></TD> | ||
+ | <TD COLSPAN=2 BGCOLOR="#D4E2EF"><B>Alternative Two</B></TD> | ||
+ | </TR> | ||
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+ | <TR ALIGN=CENTER VALIGN=MIDDLE> | ||
+ | <TD COLSPAN=2>[[Image:CoreSystemEnvZx2.png|550px]]Two copies of ''envZ''</TD> | ||
+ | <TD COLSPAN=2>[[Image:CoreSystemKeep3.png|550px]] No modifications, i.e. a single copy of ''envZ''</TD> | ||
+ | </TR> | ||
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+ | <TR ALIGN=CENTER VALIGN=MIDDLE> | ||
+ | <TD COLSPAN=2>[[Image:CoreSystemEnvZx2Activation.png|550px]] One of the copies of ''envZ'' is activated by FlhDC and Flia</TD> | ||
+ | <TD COLSPAN=2>[[Image:CoreSystemKeep3Activation.png|550px]] ''lasI'' is activated by FlhDC and Flia</TD> | ||
+ | </TR> | ||
+ | |||
+ | |||
+ | <TR ALIGN=CENTER VALIGN=MIDDLE> | ||
+ | <TD COLSPAN=2>[[Image:CoreSystemEnvZx2ActivationInhibition.png|550px]] EnvZ inhibits the expression of ''lasI''</TD> | ||
+ | <TD COLSPAN=2>[[Image:CoreSystemKeep3ActivationNoInhibition.png|550px]] EnvZ does not inhibit the expression of ''lasI''</TD> | ||
+ | </TR> | ||
+ | |||
+ | <TR ALIGN=CENTER VALIGN=MIDDLE> | ||
+ | <TD COLSPAN=2>[[Image:TwoModules.png|550px]] This system ends up with 2 modules </TD> | ||
+ | <TD COLSPAN=2>[[Image:SingleModule.png|550px]] This system consists of a single module</TD> | ||
+ | </TR> | ||
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+ | <TR ALIGN=CENTER VALIGN=MIDDLE> | ||
+ | <TD COLSPAN=2>[[Image:Bimo.png|550px]]Core system coupled with an oscillator</TD> | ||
+ | <TD COLSPAN=2>[[Image:Unimo.png|550px]]Modified core system that accounts for quorum sensing</TD> | ||
+ | </TR> | ||
+ | </TABLE> | ||
== Modeling Alternatives == | == Modeling Alternatives == |
Revision as of 12:55, 28 October 2008
Model Construction
IntroductionWe are interested to understand the factors that account for an oscillating behaviour at population level. We build two models to study systems that are equipated with quorum sensing capabilities but that relay on different designs principles. joint our quest for alternatives...
Modeling AlternativesThe proposed models are:
Both the bimodular and unimodular models describe events that happend not only at the cellular level (as in the core system) but also at the population level due to interactions needed bettwen a cell and its environment during quorum sensing. In the following sections, we first describe the population modeling (the common part amoung our two proposed models) to then focus our attention to the characteristics that are exclusive to each of the modeling alternatives. Description<CENTER>
↓ more detailed description... ↑
Parameters SearchThe following table sumarize our findings. The parameters' values that are used during the simulations. Most them are found in literature others are obtained from further analysis.
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