Team:Paris/Modeling/Programs
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(→Hill Functions) |
(→Hill Functions) |
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that we can easily solve with : | that we can easily solve with : | ||
- | <center> [[Images: | + | <center> [[Images:reshill.jpg]] </center> |
Depending to the order ''' ''n'' ''' (also called ''cooperativity'', because it correponds to the possibilities of the transcription factor to binds in a group on the promoter), this function is a ''sigmoïd'', known as the ''Hill function''. The parameter ''' ''K'' ''', called ''activation constant'', is often replaced in the previous expression by the following notation | Depending to the order ''' ''n'' ''' (also called ''cooperativity'', because it correponds to the possibilities of the transcription factor to binds in a group on the promoter), this function is a ''sigmoïd'', known as the ''Hill function''. The parameter ''' ''K'' ''', called ''activation constant'', is often replaced in the previous expression by the following notation | ||
- | <center> [[Images:changeK]] </center> | + | <center> [[Images:changeK.jpg]] </center> |
It simplify the manipulations of the expression ; we can notice that ''' ''K'' ''' represents now the amount of ''TF'' needed to get half of the total ''P'' bound. | It simplify the manipulations of the expression ; we can notice that ''' ''K'' ''' represents now the amount of ''TF'' needed to get half of the total ''P'' bound. | ||
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+ | <center> [[Images:hilldef.jpg]] </center> | ||
==Finding Parameters== | ==Finding Parameters== |
Revision as of 12:13, 16 September 2008
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