Team:NYMU-Taipei

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<!-- *** What falls between these lines is the Alert Box! You can remove it from your pages once you have read and understood the alert *** -->
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<!-- [[Image:NYMU_banner 000.png|700px]]-->
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<!--[[Image:MainCartoon.png|border|center|Bac2Kidney]]-->
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You are provided with this team page template with which to start the iGEM season.  You may choose to personalize it to fit your team but keep the same "look." Or you may choose to take your team wiki to a different level and design your own wiki. You can find some examples <a href="https://2008.igem.org/Help:Template/Examples">HERE</a>.
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<dt>Banner</dt>
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<dd id="banner">
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<span><img src="/wiki/images/9/93/NYMU_Bannerinpic_700px.png" width="700" alt="BacToKidney - Toward a better quality of life"></span>
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</dd>
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<dt>pH Sensor</dt>
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<dd id="ph"><a href="./Team:NYMU-Taipei/Project/pH_Sensor" onmouseover="haxbackground();" onmouseout="unhaxbackground();">
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<span><div class="first">pH Sensor</div>
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<div class="rest">A sensor of proton concentration (pH). Activates in a high pH environment.</div></span>
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</a></dd>
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<dt>Attachment</dt>
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<span><div class="first">Attachment</div>
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<div class="rest">Attachment to the small intestine.</div></span>
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</a></dd>
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<dt>Urea</dt>
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<dd id="u"><a href="./Team:NYMU-Taipei/Project/Urea" onmouseover="haxbackground();" onmouseout="unhaxbackground();">
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<span><div class="first">Clearance of Urea</div>
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<div class="rest">A Urea clearance device.</div></span>
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</a></dd>
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<dt>Guanidine</dt>
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<dd id="g"><a href="./Team:NYMU-Taipei/Project/Guanidine" onmouseover="haxbackground();" onmouseout="unhaxbackground();">
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<span><div class="first">Clearance of Guanidine</div>
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<div class="rest">The device managing the clearance of guanidino compounds.</div></span>
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</a></dd>
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<dt>Phosphate</dt>
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<dd id="p"><a href="./Team:NYMU-Taipei/Project/Phosphate" onmouseover="haxbackground();" onmouseout="unhaxbackground();">
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<span><div class="first">Clearance of Phosphate</div>
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<div class="rest">A Phosphate clearance and balance device.</div></span>
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</a></dd>
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<dt>Time Regulation</dt>
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<dd id="time"><a href="./Team:NYMU-Taipei/Project/Time_Regulation" onmouseover="haxbackground();" onmouseout="unhaxbackground();">
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<span><div class="first">Time Regulation</div>
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<div class="rest">Using oscillators to measure time, it enables detachment from the small intestine after a certain amount of time.</div></span>
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</a></dd>
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{{:Team:NYMU-Taipei/Links}}
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<!-- *** End of the alert box *** -->
 
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{|align="justify"
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{| style="width:965px;border:1px solid gray;"
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|You can write a background of your team here.  Give us a background of your team, the members, etc.  Or tell us more about something of your choosing.
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|[[Image:Example_logo.png|200px|right|frame]]
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|-
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| style="vertical-align:top;width:50%;border-right:1px solid gray;" |  <font size="4"><b>'''BacToKidney'''</b></font> - ''Toward a better quality of life''.
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''Tell us more about your project. Give us background.  Use this is the abstract of your project. Be descriptive but concise (1-2 paragraphs)''
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<br>'''Goal:'''
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|[[Image:Team.png|right|frame|Your team picture]]
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*Use designer bacteria to replace a hemodialysis machine to remove (filter out) toxic waste for treating kidney failure.
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<br>'''Why is it an interesting problem?'''
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* Approximately 1.3 million people globally have chronic kidney failure that requires either renal transplantation or dialysis - for such patients, the established treatment is hemodialysis
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|align="center"|[[Team:NYMU-Taipei | Team Example 2]]
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* The mortality rate of patients undergoing maintenance hemodialysis remains unacceptably high.
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* An extremely high morbidity and a relatively low quality of life (due in part to a high level of dependence and unemployment) and high cost have also been observed.
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<br>'''Our Design:'''
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<!--- The Mission, Experiments --->
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* After ingesting our BacToKidney capsule, it passes the through stomach without taking any action, nor being digested, and proceeds to the small intestine. Once in the small intestine, the [[Team:NYMU-Taipei/Project/pH Sensor|pH Sensor]] detects the change in pH and activates the clearance processes of [[Team:NYMU-Taipei/Project/Urea|Urea]], [[Team:NYMU-Taipei/Project/Phosphate|Phosphate]], and [[Team:NYMU-Taipei/Project/Guanidine|Guanidine]] from the body. To allow itself more time to perform its tasks, the [[Team:NYMU-Taipei/Project/pH Sensor|pH Sensor]] also activates the [[Team:NYMU-Taipei/Project/Attachment|Attachment]] process, making the capsule attach itself to the small intestine. After a pre-selected amount of time has passed (controlled by the [[Team:NYMU-Taipei/Project/Time Regulation|time regulating oscillators]]), the capsule detaches itself from the small intestine and exits the body.
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<br>'''The parts our project is made up of:'''
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* [[Team:NYMU-Taipei/Project/pH Sensor | pH Sensor]]
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** A sensor of '''proton concentration (pH)'''
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* [[Team:NYMU-Taipei/Project/Attachment | Attachment]]
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** An '''Attachment anchor''' that attaches to the small intestine
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* [[Team:NYMU-Taipei/Project/Urea | Clearance of Urea]]
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** A '''Urea''' clearance device
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* [[Team:NYMU-Taipei/Project/Phosphate | Clearance of Phosphate]]
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** A '''Phosphate''' clearance and balance device
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* [[Team:NYMU-Taipei/Project/Guanidine | Clearance of Guanidine]]
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** A '''Guanidine''' clearance device
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* [[Team:NYMU-Taipei/Project/Time Regulation | Time Regulation]]
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** Enables detachment from the small intestine after a certain amount of time
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** Experimenting with two systems:
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*** [[Team:NYMU-Taipei/Project/Time_Regulation/Cyanoxilator|Cyanoxilator]]: A tuneable cyanobacterial natural (sinusoidal) oscillator implemented in ''E. coli''.
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*** [[Team:NYMU-Taipei/Project/Time_Regulation/Reloxilator|Reloxilator]]: A tuneable intracell-synchronized relaxation oscillator.
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{| style="color:#1b2c8a;background-color:#0c6;" cellpadding="3" cellspacing="1" border="1" bordercolor="#fff" width="62%" align="center"
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| style="vertical-align:top;" | {{:Team:NYMU-Taipei/News}} <!-- Edit the News page for news please. -->
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!align="center"|[[Team:NYMU-Taipei|Home]]
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!align="center"|[[Team:NYMU-Taipei/Team|The Team]]
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!align="center"|[[Team:NYMU-Taipei/Project|The Project]]
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!align="center"|[[Team:NYMU-Taipei/Parts|Parts Submitted to the Registry]]
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!align="center"|[[Team:NYMU-Taipei/Modeling|Modeling]]
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!align="center"|[[Team:NYMU-Taipei/Notebook|Notebook]]
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|}
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(''Or you can choose different headings.  But you must have a team page, a project page, and a notebook page.'')
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{{:Team:NYMU-Taipei/Footer}}

Latest revision as of 02:41, 29 October 2008


Banner
pH Sensor
pH Sensor
A sensor of proton concentration (pH). Activates in a high pH environment.
Attachment
Attachment
Attachment to the small intestine.
Urea
Clearance of Urea
A Urea clearance device.
Guanidine
Clearance of Guanidine
The device managing the clearance of guanidino compounds.
Phosphate
Clearance of Phosphate
A Phosphate clearance and balance device.
Time Regulation
Time Regulation
Using oscillators to measure time, it enables detachment from the small intestine after a certain amount of time.



BacToKidney - Toward a better quality of life.


Goal:

  • Use designer bacteria to replace a hemodialysis machine to remove (filter out) toxic waste for treating kidney failure.


Why is it an interesting problem?

  • Approximately 1.3 million people globally have chronic kidney failure that requires either renal transplantation or dialysis - for such patients, the established treatment is hemodialysis
  • The mortality rate of patients undergoing maintenance hemodialysis remains unacceptably high.
  • An extremely high morbidity and a relatively low quality of life (due in part to a high level of dependence and unemployment) and high cost have also been observed.


Our Design:

  • After ingesting our BacToKidney capsule, it passes the through stomach without taking any action, nor being digested, and proceeds to the small intestine. Once in the small intestine, the pH Sensor detects the change in pH and activates the clearance processes of Urea, Phosphate, and Guanidine from the body. To allow itself more time to perform its tasks, the pH Sensor also activates the Attachment process, making the capsule attach itself to the small intestine. After a pre-selected amount of time has passed (controlled by the time regulating oscillators), the capsule detaches itself from the small intestine and exits the body.


The parts our project is made up of:

News and Updates.
  • 2008-10-28: Gradually migrating the wiki pages to here.
  • 2008-08-12: The team page now displays us.
  • 2008-08-06: New Wikipage design put up!
  • 2008-08-01: Wikipage Online!

Retrieved from "http://2008.igem.org/Team:NYMU-Taipei"