Team:KULeuven
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- | #kul div {text-align: justify;} | + | <style type="text/css"> |
+ | #bioscenter-box {background: #5cc7dd;} | ||
+ | #kuleuven-box {background: #77ffff;} | ||
+ | #team-box {background: #ffff88;} | ||
+ | #project-box {background: #aadd66;} | ||
+ | #modeling-box {background: #77ffff;} | ||
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+ | #kul div {text-align: justify;} | ||
</style> | </style> | ||
+ | |||
+ | <!-- CSS: IE FIXES --> | ||
+ | <!--[if IE]> | ||
+ | <style type="text/css"> | ||
+ | #home-content>div {border-color:#747474;} | ||
+ | #home-sidebar table.month {margin:0 auto;background-color:transparent;} | ||
+ | </style> | ||
+ | <![endif]--> | ||
<!-- JAVASCRIPT --> | <!-- JAVASCRIPT --> | ||
- | <script type="text/javascript" src="http://www | + | <script type="text/javascript" src="http://www.kuleuven.be/bioscenter/igem/js/ui.core.js"></script> |
- | <script type="text/javascript" src="http://www | + | <script type="text/javascript" src="http://www.kuleuven.be/bioscenter/igem/js/ui.tabs.js"></script> |
+ | <script type="text/javascript" src="http://www.kuleuven.be/bioscenter/igem/js/jquery.corner.js"></script> | ||
<script type="text/javascript"> | <script type="text/javascript"> | ||
$(function() { | $(function() { | ||
- | + | $('#bioscenter-box > ul').tabs({ fx: { opacity: 'toggle', height: 'toggle'} }); | |
- | + | $('#kuleuven-box > ul').tabs({ fx: { opacity: 'toggle', height: 'toggle'} }); | |
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+ | $('#bioscenter-box').corner("bottom"); | ||
+ | $('#kuleuven-box').corner("bottom"); | ||
+ | $('#team-box').corner("bottom"); | ||
+ | $('#project-box').corner("bottom"); | ||
+ | $('#modeling-box').corner("bottom"); | ||
}); | }); | ||
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function CngTxt(id,txt){ | function CngTxt(id,txt){ | ||
var obj=document.getElementById(id); | var obj=document.getElementById(id); | ||
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+ | <!-- Script for preloading images into webpage --> | ||
<script type="text/javascript"> | <script type="text/javascript"> | ||
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Image1.src = "https://static.igem.org/mediawiki/2008/1/17/StudentsKULBlackWhite.JPG" | Image1.src = "https://static.igem.org/mediawiki/2008/1/17/StudentsKULBlackWhite.JPG" | ||
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+ | <div id="home"> | ||
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+ | <div class="alert-box"> | ||
+ | Our wiki has been frozen. For future updates we advise you to redirect to iGEM's <a href="https://2008.igem.org/Main_Page">Main Page</a>. To follow our adventure at the Jamboree in Boston, keep an eye on our online <a href="http://igemkuleuven.wordpress.com/">BLOG</a>. | ||
+ | </div> | ||
+ | </html> | ||
- | < | + | <br /> |
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- | + | <html> | |
+ | <!-- HEADER --> | ||
+ | <div id="home-header" style="overflow:hidden"> | ||
- | <div | + | <!-- COUNTDOWN --> |
+ | <div class="countdown"> | ||
+ | <div style="float:left;clear:both"> | ||
+ | <embed src="http://www.oneplusyou.com/bb/files/countdown/countdown.swf?co=075A90&date_month=11&date_day=09&date_year=1&un=IGEM JAMBOREE 2008&size=normal&mo=11&da=09&yr=2008" type="application/x-shockwave-flash" pluginspage="http://www.macromedia.com/go/getflashplayer" width="240" height="80" wmode="transparent"></embed> | ||
+ | </div> | ||
+ | <div style="float:left;clear:both;background:white;width:240px;height:20px"></div> | ||
+ | </div> | ||
- | < | + | <h2>Welcome to the KULeuven IGEM 2008 Homepage!</h2> |
- | <div id=" | + | <p>Enjoy the hard work we delivered, feel free to contact us at <a href="mailto:igem@kuleuven.be?SUBJECT=IGEM 2008">igem@kuleuven.be</a> and visit our university/sponsor (<a href="http://www.kuleuven.be/bioscenter">BioSCENTer</a>) <a href="http://www.kuleuven.be/bioscenter/igem"><b>iGEM page</b></a>!</p> |
+ | |||
+ | </div> | ||
+ | |||
+ | <!-- MAIN --> | ||
+ | <div id="home-main"> | ||
- | <!-- | + | <!-- CONTENT --> |
- | <div id=" | + | <div id="home-content"> |
- | <!-- | + | <!-- CONTENT: BIOSCENTER --> |
<div id="bioscenter-box"> | <div id="bioscenter-box"> | ||
- | + | <h3>Synthetic Biology: BioSCENTer and iGEM</h3> | |
- | + | <ul> | |
- | + | <li><a href="#bioscenter-1"><span>On Synthetic Biology</span></a></li> | |
- | + | <li><a href="#bioscenter-2"><span>On IGEM</span></a></li> | |
- | + | </ul> | |
- | <!-- | + | <!-- CONTENT: BIOSCENTER: SYNTHETIC BIOLOGY --> |
<div id="bioscenter-1"> | <div id="bioscenter-1"> | ||
<p> | <p> | ||
- | <a href="http://syntheticbiology.org">Synthetic biology</a> is a new challenge in biosciences. It combines biology and engineering principles to design and build new biological functions and systems. Examples are abound: cancer cell invading bacteria, microbes that take pictures, antimalarial drug producers,... The advantage of using living systems for these purposes is that, once they are designed and built, they are self-reproducible. The challenge, however lies exactly within the design and construction: making biological circuits and devices as robust and predictive as their electrical counterparts. ... | + | <a href="http://syntheticbiology.org">Synthetic biology</a> is a new challenge in biosciences. It combines biology and engineering principles to design and build new biological functions and systems. Examples are abound: cancer cell invading bacteria, microbes that take pictures, antimalarial drug producers,... The advantage of using living systems for these purposes is that, once they are designed and built, they are self-reproducible. The challenge, however, lies exactly within the design and construction: making biological circuits and devices as robust and predictive as their electrical counterparts. <a href="http://www.kuleuven.be/bioscenter/igem/?go=syntheticbiology">...</a> |
</p> | </p> | ||
- | <ul class=" | + | <ul class="more"> |
<li><a href="http://www.kuleuven.be/bioscenter/igem/?go=syntheticbiology">Read the whole page</a></li> | <li><a href="http://www.kuleuven.be/bioscenter/igem/?go=syntheticbiology">Read the whole page</a></li> | ||
</ul> | </ul> | ||
</div> | </div> | ||
- | <!-- | + | <!-- CONTENT: BIOSCENTER: IGEM --> |
<div id="bioscenter-2"> | <div id="bioscenter-2"> | ||
<img class="floatright" src="https://static.igem.org/mediawiki/2008/1/1e/IGEM_logo_1.png" /> | <img class="floatright" src="https://static.igem.org/mediawiki/2008/1/1e/IGEM_logo_1.png" /> | ||
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The core of the iGEM competition is to design and build a “new genetic machine” with <a href="http://partsregistry.org">BioBricks</a>. BioBricks are standardized, off the shelf biological parts that are used by genetic network designers. All BioBricks that were made during previous iGEM competitions are registered and documented in the Registry of Standard Biological Parts. Each iGEM competition thus starts from the efforts of the previous years. | The core of the iGEM competition is to design and build a “new genetic machine” with <a href="http://partsregistry.org">BioBricks</a>. BioBricks are standardized, off the shelf biological parts that are used by genetic network designers. All BioBricks that were made during previous iGEM competitions are registered and documented in the Registry of Standard Biological Parts. Each iGEM competition thus starts from the efforts of the previous years. | ||
</p> | </p> | ||
- | <ul class=" | + | <ul class="more"> |
<li><a href="http://www.kuleuven.be/bioscenter/igem/?go=competition">Read the whole page</a></li> | <li><a href="http://www.kuleuven.be/bioscenter/igem/?go=competition">Read the whole page</a></li> | ||
<li><a href="http://www.kuleuven.be/bioscenter/igem/?go=people2008">More on our team</a></li> | <li><a href="http://www.kuleuven.be/bioscenter/igem/?go=people2008">More on our team</a></li> | ||
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</div> | </div> | ||
- | <!-- | + | <!-- CONTENT: KULEUVEN --> |
<div id="kuleuven-box"> | <div id="kuleuven-box"> | ||
- | + | <h3>Leuven</h3> | |
- | + | <ul> | |
- | + | <li><a href="#kuleuven-1"><span>KULeuven</span></a></li> | |
- | + | </ul> | |
- | <!-- | + | <!-- CONTENT: KULEUVEN DESCRIPTION --> |
<div id="kuleuven-1"> | <div id="kuleuven-1"> | ||
<img class="floatright" width="300" heigth="300" src="https://static.igem.org/mediawiki/2008/5/59/Leuven_by_night.jpg" /> | <img class="floatright" width="300" heigth="300" src="https://static.igem.org/mediawiki/2008/5/59/Leuven_by_night.jpg" /> | ||
<p> | <p> | ||
- | The University of Leuven was founded almost six hundred years ago. Throughout the centuries people have always occupied center stage at the <a href="http://www.kuleuven.be/english"> | + | The University of Leuven was founded almost six hundred years ago. Throughout the centuries people have always occupied center stage at the <a href="http://www.kuleuven.be/english">Katholieke Universiteit Leuven</a>. |
The University's academic fame has attracted scholars and scientists as Justus Lipsius, Gerard Mercator and Andreas Vesalius who have all made valuable contribution to the European intellectual life. | The University's academic fame has attracted scholars and scientists as Justus Lipsius, Gerard Mercator and Andreas Vesalius who have all made valuable contribution to the European intellectual life. | ||
The University of Leuven can look back on a glorious past, but it also moves with the times. | The University of Leuven can look back on a glorious past, but it also moves with the times. | ||
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</div> | </div> | ||
- | <!-- | + | <!-- CONTENT: TEAM --> |
<div id="team-box"> | <div id="team-box"> | ||
- | + | <h3>The Team</h3> | |
- | + | <ul> | |
- | + | <li><a href="#team-1"><span>Meet the team</span></a></li> | |
- | + | </ul> | |
- | <!-- | + | <!-- CONTENT: TEAM: IMAGE MAP --> |
<div id="team-1"> | <div id="team-1"> | ||
<p> | <p> | ||
- | The KULeuven team consists of 12 enthusiastic students selected out of three faculties, 4 civil engineers, 4 bio-engineers and 4 biochemists. More information on the team members can be found on the <a href="https://2008.igem.org/Team:KULeuven/Team/Students">Students | + | The KULeuven team consists of 12 enthusiastic students selected out of three faculties, 4 civil engineers, 4 bio-engineers and 4 biochemists. More information on the team members can be found on the <a href="https://2008.igem.org/Team:KULeuven/Team/Students">Students page</a> or by scrolling over the heads of the students. |
</p> | </p> | ||
<script> | <script> | ||
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</script> | </script> | ||
<dl id="cartoonmap"> | <dl id="cartoonmap"> | ||
- | + | <dt>Maarten Breckpot</dt> | |
- | + | <dd id="maarten"><a href="https://2008.igem.org/User:Maarten" onmouseover="haxbackground();" onmouseout="unhaxbackground();"> | |
- | + | <span><div class="first">Maarten Breckpot</div> | |
- | + | <div class="rest"> <br> <b><font size="2.5">Studies:</font></b> <br> <font size="2"> 1st Master of Applied Sciences and Engineering – Mathematical Engineering </font> <br> <b><font size="2.5">Country:</font></b> <br> <font size="2"> Belgium</font> </div></span> | |
- | + | </a></dd> | |
- | + | <dt>Nick Van Damme</dt> | |
- | + | <dd id="nick"><a href="https://2008.igem.org/User:Nickvd" onmouseover="haxbackground();" onmouseout="unhaxbackground();"> | |
- | + | <span><div class="first">Nick Van Damme</div> | |
- | + | <div class="rest"><br> <b><font size="2.5">Studies:</font></b> <br> <font size="2"> 1st Master of Applied Sciences and Engineering – Mathematical Engineering </font> <br> <b><font size="2.5">Country:</font></b> <br> <font size="2"> Belgium</font> </div></span> | |
- | + | </a></dd> | |
<dt>Benjamien Moeyaert</dt> | <dt>Benjamien Moeyaert</dt> | ||
- | + | <dd id="benjamien"><a href="https://2008.igem.org/User:Bmoeyaert" onmouseover="haxbackground();" onmouseout="unhaxbackground();"> | |
- | + | <span><div class="first">Benjamien Moeyaert</div> | |
- | + | <div class="rest"><br> <b><font size="2.5">Studies:</font></b> <br> <font size="2"> 3rd Bachelor of Biochemistry and Biotechnology</font> <br> <b><font size="2.5">Country:</font></b> <br> <font size="2"> Belgium</font> </div></span> | |
- | + | </a></dd> | |
<dt>Stefanie Roberfroid</dt> | <dt>Stefanie Roberfroid</dt> | ||
- | + | <dd id="stefanie"><a href="https://2008.igem.org/User:Stefanie" onmouseover="haxbackground();" onmouseout="unhaxbackground();"> | |
- | + | <span><div class="first">Stefanie Roberfroid</div> | |
- | + | <div class="rest"><br> <b><font size="2.5">Studies:</font></b> <br> <font size="2"> 3rd Bachelor of Bioscience Engineering – Biomolecular Engineering</font> <br> <b><font size="2.5">Country:</font></b> <br> <font size="2"> Belgium</font> </div></span> | |
- | + | </a></dd> | |
<dt>Dries Vercruysse</dt> | <dt>Dries Vercruysse</dt> | ||
- | + | <dd id="dries"><a href="https://2008.igem.org/User:Dries" onmouseover="haxbackground();" onmouseout="unhaxbackground();"> | |
- | + | <span><div class="first">Dries Vercruysse</div> | |
- | + | <div class="rest"><br> <b><font size="2.5">Studies:</font></b> <br> <font size="2"> 1st Master of Applied Sciences and Engineering - Nanoscience and Nanotechnology</font> <br> <b><font size="2.5">Country:</font></b> <br> <font size="2"> Belgium</font> </div></span> | |
- | + | </a></dd> | |
<dt>Andim Doldurucu</dt> | <dt>Andim Doldurucu</dt> | ||
- | + | <dd id="andim"><a href="https://2008.igem.org/User:Andim" onmouseover="haxbackground();" onmouseout="unhaxbackground();"> | |
- | + | <span><div class="first">Andim Doldurucu</div> | |
- | + | <div class="rest"><br> <b><font size="2.5">Studies:</font></b> <br> <font size="2"> 1st Master of Bioscience Engineering – Nanoscience and Nanotechnology</font> <br> <b><font size="2.5">Country:</font></b> <br> <font size="2"> Turkey </font> </div></span> | |
- | + | </a></dd> | |
<dt>Hanne Tytgat</dt> | <dt>Hanne Tytgat</dt> | ||
- | + | <dd id="hanne"><a href="https://2008.igem.org/User:Hanne" onmouseover="haxbackground();" onmouseout="unhaxbackground();"> | |
- | + | <span><div class="first">Hanne Tytgat</div> | |
- | + | <div class="rest"><br> <b><font size="2.5">Studies:</font></b> <br> <font size="2"> 3rd Bachelor of Biochemistry and Biotechnology</font> <br> <b><font size="2.5">Country:</font></b> <br> <font size="2"> Belgium</font> </div></span> | |
- | + | </a></dd> | |
<dt>Elke Van Assche</dt> | <dt>Elke Van Assche</dt> | ||
- | + | <dd id="elke"><a href="" onmouseover="haxbackground();" onmouseout="unhaxbackground();"> | |
- | + | <span><div class="first">Elke Van Assche</div> | |
- | + | <div class="rest"><br> <b><font size="2.5">Studies:</font></b> <br> <font size="2"> 3rd Bachelor of Bioscience Engineering – Biomolecular Engineering</font> <br> <b><font size="2.5">Country:</font></b> <br> <font size="2"> Belgium</font> </div></span> | |
- | + | </a></dd> | |
<dt>Jan Mertens</dt> | <dt>Jan Mertens</dt> | ||
- | + | <dd id="jan"><a href="https://2008.igem.org/User:Jotaro" onmouseover="haxbackground();" onmouseout="unhaxbackground();"> | |
- | + | <span><div class="first">Jan Mertens</div> | |
- | + | <div class="rest"><br> <b><font size="2.5">Studies:</font></b> <br> <font size="2"> 1st Master of Bioscience Engineering – Biomolecular Engineering</font> <br> <b><font size="2.5">Country:</font></b> <br> <font size="2"> Belgium</font> </div></span> | |
- | + | </a></dd> | |
<dt>Nathalie Busschaert</dt> | <dt>Nathalie Busschaert</dt> | ||
- | + | <dd id="nathalie"><a href="https://2008.igem.org/User:BNathalie" onmouseover="haxbackground();" onmouseout="unhaxbackground();"> | |
- | + | <span><div class="first">Nathalie Busschaert</div> | |
- | + | <div class="rest"><br> <b><font size="2.5">Studies:</font></b> <br> <font size="2"> 3rd Bachelor of Chemistry </font> <br> <b><font size="2.5">Country:</font></b> <br> <font size="2"> Belgium</font> </div></span> | |
- | + | </a></dd> | |
<dt>Jonas Demeulemeester</dt> | <dt>Jonas Demeulemeester</dt> | ||
- | + | <dd id="jonas"><a href="https://2008.igem.org/User:Zeunas" onmouseover="haxbackground();" onmouseout="unhaxbackground();"> | |
- | + | <span><div class="first">Jonas Demeulemeester</div> | |
- | + | <div class="rest"><br> <b><font size="2.5">Studies:</font></b> <br> <font size="2"> 1st Master of Biochemistry and Biotechnology</font> <br> <b><font size="2.5">Country:</font></b> <br> <font size="2"> Belgium</font> </div></span> | |
- | + | </a></dd> | |
<dt>Antoine Vandermeersch</dt> | <dt>Antoine Vandermeersch</dt> | ||
- | + | <dd id="antoine"><a href="https://2008.igem.org/User:Avdmeers" onmouseover="haxbackground();" onmouseout="unhaxbackground();"> | |
- | + | <span><div class="first">Antoine Vandermeersch</div> | |
- | + | <div class="rest"> | |
<br> <b><font size="2.5">Studies:</font></b> <br> <font size="2"> 2nd and 3rd Bachelor of Applied Sciences and Engineering – Electrical and Materials Engineering </font> <br> <b><font size="2.5">Country:</font></b> <br> <font size="2"> Belgium</font> | <br> <b><font size="2.5">Studies:</font></b> <br> <font size="2"> 2nd and 3rd Bachelor of Applied Sciences and Engineering – Electrical and Materials Engineering </font> <br> <b><font size="2.5">Country:</font></b> <br> <font size="2"> Belgium</font> | ||
</div></span> | </div></span> | ||
- | + | </a></dd> | |
</dl> | </dl> | ||
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</div> | </div> | ||
- | <!-- | + | <!-- CONTENT: PROJECT --> |
<div id="project-box"> | <div id="project-box"> | ||
- | + | <h3>The Project</h3> | |
- | + | <ul> | |
- | + | <li><a href="#project-1"><span>Project</span></a></li> | |
- | + | </ul> | |
- | <!-- | + | <!-- CONTENT: PROJECT: SUBSYSTEMS --> |
<div id="project-1"> | <div id="project-1"> | ||
<p> | <p> | ||
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</div> | </div> | ||
- | <!-- | + | <!-- CONTENT: MODELING --> |
<div id="modeling-box"> | <div id="modeling-box"> | ||
- | + | <h3>Modeling</h3> | |
- | + | <ul> | |
- | + | <li><a href="#modeling-1"><span>Introducing engineering</span></a></li> | |
- | + | <li><a href="#modeling-2"><span>Adding reality</span></a></li> | |
- | + | <li><a href="#modeling-3"><span>Assembling the model</span></a></li> | |
- | + | </ul> | |
- | <!-- | + | <!-- CONTENT: MODELING: ENGINEERING --> |
<div id="modeling-1"> | <div id="modeling-1"> | ||
- | <img | + | <img class="floatright" width="140" heigth="170" src="https://static.igem.org/mediawiki/2008/4/4e/Model_homepage.PNG" /> |
+ | <p> | ||
+ | The most important assets of our project are the different control mechanisms. Since these are very much dependent on kinetic and other constants, Dr. Coli heavily relies on proper <a href="https://2008.igem.org/Team:KULeuven/Model/Overview">modeling</a>. Our Dry-Lab team has spent its summer setting up a computational model of Dr. Coli to completely simulate his actions. We constructed models of all the subsystems (components) in both CellDesigner and Matlab. All these subsystems have been characterised by their ODE's and have been simulated thoroughly. Together they form our <a href="https://2008.igem.org/Team:KULeuven/Model/FullModel">full model</a> of Dr. Coli. These models are only capable of simulating the behaviour of one Dr. Coli cell, so we implemented our own Software Tool that can work with <a href="https://2008.igem.org/Team:KULeuven/Model/MultiCell">multi cellular models</a>. | ||
+ | </p> | ||
</div> | </div> | ||
- | |||
- | |||
<div id="modeling-2"> | <div id="modeling-2"> | ||
- | <img src=" | + | <p style="text-align:center"> |
+ | <img src="https://static.igem.org/mediawiki/2008/8/86/5652strip.gif" border="0" alt="Parameters are everything" /> | ||
+ | </p> | ||
+ | <p> | ||
+ | After building the model frame, it was time to add the physical relevance to it. Kinetic constants were searched for and investigated by means of previous iGEM teams (e.g. <a href="https://2007.igem.org/title=ETHZ/Parameters">ETHZ 2007</a>), the parts characterizations on the Registry of Standard Biological Parts and popular biological literature databases such as <a href="http://www.hubmed.org">Hubmed</a>, ... | ||
+ | Our own contribution would revolve around <a href="https://2008.igem.org/Team:KULeuven/Data/Overview">data analysis</a> of the produced parts. | ||
+ | </p> | ||
</div> | </div> | ||
- | |||
<div id="modeling-3"> | <div id="modeling-3"> | ||
- | <img | + | <p style="text-align:center"> |
+ | <img src="https://static.igem.org/mediawiki/2008/f/f8/10797strip.gif" border="0" alt="Dilbert.com" /> | ||
+ | </p> | ||
+ | <p> | ||
+ | Working with concepts as modularity and abstraction, we worked out every subsystem (Output, Memory, Filter, ...) to eventually merge them all in our <a href="https://2008.igem.org/Team:KULeuven/Model/FullModel">full model</a>. By trial and error the system was adapted to achieve desired output quantities (amount of molecules, proteins, ...) given a representative input. | ||
+ | </p> | ||
<p> | <p> | ||
- | + | To take it a step further, a <a href="https://2008.igem.org/Team:KULeuven/Model/MultiCell">multi-cell model</a> was build, to analyse crucial steps in cell division (e.g. Memory inheritance). | |
+ | A <a href="https://2008.igem.org/Team:KULeuven/Model/Diffusion">diffusion model</a> was made to investigate HSL diffusion towards neighbouring cells and see what effects this generated on their <a href="https://2008.igem.org/Team:KULeuven/Project/Inverter">Invertimer</a> system. | ||
</p> | </p> | ||
</div> | </div> | ||
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- | < | + | <div id="cboxdiv" style="text-align: center; line-height: 0"> |
+ | <div><iframe frameborder="0" width="190" height="145" src="http://www4.cbox.ws/box/?boxid=3561013&boxtag=4303&sec=main" marginheight="2" marginwidth="2" scrolling="auto" allowtransparency="yes" name="cboxmain" style="border:#075A90 1px solid;" id="cboxmain"></iframe></div> | ||
+ | <div><iframe frameborder="0" width="190" height="75" src="http://www4.cbox.ws/box/?boxid=3561013&boxtag=4303&sec=form" marginheight="2" marginwidth="2" scrolling="no" allowtransparency="yes" name="cboxform" style="border:#075A90 1px solid;border-top:0px" id="cboxform"></iframe></div> | ||
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<h3>Interesting Links</h3> | <h3>Interesting Links</h3> | ||
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<li>[http://partsregistry.org/Main_Page Registry of Standard Biological Parts]</li> | <li>[http://partsregistry.org/Main_Page Registry of Standard Biological Parts]</li> | ||
<li>[http://www.kuleuven.be/bioscenter BioSCENTer]</li> | <li>[http://www.kuleuven.be/bioscenter BioSCENTer]</li> | ||
+ | </ul> | ||
+ | <ul class="general-links"> | ||
+ | <li>[[Team:KULeuven/Software/MultiCell|KUL MultiCell Toolbox]]</li> | ||
+ | <li>[[Team:KULeuven/Software/Simbiology2LaTeX|KUL Simbiology2LaTeX Toolbox]]</li> | ||
+ | <li>[[Team:KULeuven/Tools/Navigation_Bar|KUL Dropdown (utility)]]</li> | ||
+ | <li>[[Team:KULeuven/Tools/New_Day/Date_Retriever|KUL Notebook (utility)]]</li> | ||
</ul> | </ul> | ||
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+ | <!-- SIDEBAR: FUN STUFF --> | ||
+ | <div class="sidebox fun-stuff"> | ||
+ | <h3>Fun Stuff</h3> | ||
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<p> | <p> | ||
- | <a href=" | + | <a href="https://static.igem.org/mediawiki/2008/5/50/Microbe-kombat.swf" onClick="return popup(this,'notes')"><img src="https://static.igem.org/mediawiki/2008/a/aa/Microbe-kombat.png">Microbe Kombat</a> |
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</p> | </p> | ||
<p> | <p> | ||
- | <a href=" | + | <a href="https://static.igem.org/mediawiki/2008/8/81/Bacteria.swf" onClick="return popup(this,'notes')"><img src="https://static.igem.org/mediawiki/2008/1/10/Bacteria_Cannibals.png">Bacteria Cannibals</a> |
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</p> | </p> | ||
<p> | <p> | ||
- | <a href=" | + | <a href="https://static.igem.org/mediawiki/2008/4/46/Dna-double_helix.swf" onClick="return popup(this,'notes')"><img src="https://static.igem.org/mediawiki/2008/1/1b/Helix-intro.png">Double Helix</a> |
</p> | </p> | ||
<p> | <p> | ||
- | <a href=" | + | <a href="https://static.igem.org/mediawiki/2008/f/f6/Bacteria_pairs.swf" onClick="return popup(this,'notes')"><img src="https://static.igem.org/mediawiki/2008/e/e5/Bacteria_pairs.PNG">Bacteria Pairs</a> |
</p> | </p> | ||
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+ | <a href="https://static.igem.org/mediawiki/2008/8/85/Bacteria_solitaire.swf" onClick="return popup(this,'notes')"><img src="https://static.igem.org/mediawiki/2008/d/d9/Bacteria_solitaire.PNG">Bacteria Solitaire</a> | ||
+ | </p> | ||
+ | |||
+ | <p> | ||
+ | <a href="https://static.igem.org/mediawiki/2008/1/12/MathAttack.swf" onClick="return popup(this,'notes')"><img src="https://static.igem.org/mediawiki/2008/e/e7/Math_Attack.png">Math Attack</a> | ||
+ | </p> | ||
+ | |||
+ | <ul class="general-links"> | ||
+ | <li><a href="http://www.youtube.com/watch?v=x5yPkxCLads" target="blank">PCR song</a></li> | ||
+ | </ul> | ||
</div> | </div> | ||
+ | </html> | ||
- | <!-- | + | <!-- SIDEBAR: NOTEBOOK --> |
<div class="sidebox"> | <div class="sidebox"> | ||
<h3>Notebook ({{CURRENTMONTHNAME}})</h3> | <h3>Notebook ({{CURRENTMONTHNAME}})</h3> | ||
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- | <div class=" | + | <ul> |
- | < | + | <li><strong>Amount:</strong> <a><img src="http://www.yourhitstats.com/Buy_Links-3717204.png" rel="nofollow" alt="Amount of visitors"></a></li> |
- | + | <li><a target="blank" href="http://www4.clustrmaps.com/counter/maps.php?url=https://2008.igem.org/Team:KULeuven" rel="nofollow" id="clustrMapsLink"><img src="http://www4.clustrmaps.com/counter/index2.php?url=https://2008.igem.org/Team:KULeuven" style="border:0px;" alt="Locations of visitors to this page" title="Locations of visitors to this page" id="clustrMapsImg" onerror="this.onerror=null; this.src='http://www2.clustrmaps.com/images/clustrmaps-back-soon.jpg'; document.getElementById('clustrMapsLink').href='http://www2.clustrmaps.com';" /></a></li> | |
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Latest revision as of 11:18, 30 October 2008
Welcome to the KULeuven IGEM 2008 Homepage!
Enjoy the hard work we delivered, feel free to contact us at igem@kuleuven.be and visit our university/sponsor (BioSCENTer) iGEM page!
Synthetic Biology: BioSCENTer and iGEM
Synthetic biology is a new challenge in biosciences. It combines biology and engineering principles to design and build new biological functions and systems. Examples are abound: cancer cell invading bacteria, microbes that take pictures, antimalarial drug producers,... The advantage of using living systems for these purposes is that, once they are designed and built, they are self-reproducible. The challenge, however, lies exactly within the design and construction: making biological circuits and devices as robust and predictive as their electrical counterparts. ...
The international Genetically Engineered Machine competition (iGEM) or iGEM competition is a synthetic biology competition for multidisciplinary teams of undergraduate students. It was first organized in 2004 by Drew Endy, Randy Rettberg and Tom Knight of MIT with two goals in mind: to yield new ideas in synthetic biology and to form the future researchers in this new scientific community. Whereas 5 US teams competed in 2004, the 2007 edition already had 750 students and advisors grouped in 54 teams from 19 countries. This year, the competition already counts 83 teams!
The core of the iGEM competition is to design and build a “new genetic machine” with BioBricks. BioBricks are standardized, off the shelf biological parts that are used by genetic network designers. All BioBricks that were made during previous iGEM competitions are registered and documented in the Registry of Standard Biological Parts. Each iGEM competition thus starts from the efforts of the previous years.
Leuven
The University of Leuven was founded almost six hundred years ago. Throughout the centuries people have always occupied center stage at the Katholieke Universiteit Leuven. The University's academic fame has attracted scholars and scientists as Justus Lipsius, Gerard Mercator and Andreas Vesalius who have all made valuable contribution to the European intellectual life. The University of Leuven can look back on a glorious past, but it also moves with the times. The University's educational concept is modern, with research activities focused on the needs and aspirations of contemporary people and society. The University of Leuven is famous not just within the borders of Belgium, but far beyond as well. Being a very lively city of and for students, Leuven aspires to maintain that reputation. In contrast to most university cities, Leuven does not have a closed campus. The University buildings are spread throughout the city and were originally built for completely different purposes.
The Team
The KULeuven team consists of 12 enthusiastic students selected out of three faculties, 4 civil engineers, 4 bio-engineers and 4 biochemists. More information on the team members can be found on the Students page or by scrolling over the heads of the students.
- Maarten Breckpot
-
Maarten Breckpot
Studies:
1st Master of Applied Sciences and Engineering – Mathematical Engineering
Country:
Belgium - Nick Van Damme
-
Nick Van Damme
Studies:
1st Master of Applied Sciences and Engineering – Mathematical Engineering
Country:
Belgium - Benjamien Moeyaert
-
Benjamien Moeyaert
Studies:
3rd Bachelor of Biochemistry and Biotechnology
Country:
Belgium - Stefanie Roberfroid
-
Stefanie Roberfroid
Studies:
3rd Bachelor of Bioscience Engineering – Biomolecular Engineering
Country:
Belgium - Dries Vercruysse
-
Dries Vercruysse
Studies:
1st Master of Applied Sciences and Engineering - Nanoscience and Nanotechnology
Country:
Belgium - Andim Doldurucu
-
Andim Doldurucu
Studies:
1st Master of Bioscience Engineering – Nanoscience and Nanotechnology
Country:
Turkey - Hanne Tytgat
-
Hanne Tytgat
Studies:
3rd Bachelor of Biochemistry and Biotechnology
Country:
Belgium - Elke Van Assche
-
Elke Van Assche
Studies:
3rd Bachelor of Bioscience Engineering – Biomolecular Engineering
Country:
Belgium - Jan Mertens
-
Jan Mertens
Studies:
1st Master of Bioscience Engineering – Biomolecular Engineering
Country:
Belgium - Nathalie Busschaert
-
Nathalie Busschaert
Studies:
3rd Bachelor of Chemistry
Country:
Belgium - Jonas Demeulemeester
-
Jonas Demeulemeester
Studies:
1st Master of Biochemistry and Biotechnology
Country:
Belgium - Antoine Vandermeersch
-
Antoine Vandermeersch
Studies:
2nd and 3rd Bachelor of Applied Sciences and Engineering – Electrical and Materials Engineering
Country:
Belgium
The Project
Our team’s project is Dr. Coli, an E. coli bacterium that produces a drug when and where it is needed in the human body. It does this in an intelligent way, such that the drug production meets the individual patient’s needs. And when the patient is cured, Dr. Coli eliminates itself from the body. To achieve this goal we divided our project into several subsystems. A detailed description about every subsystem can be found by clicking on one of the following pictograms.
scroll over the pictograms to get a short description or click on them to go to the corresponding page
Modeling
The most important assets of our project are the different control mechanisms. Since these are very much dependent on kinetic and other constants, Dr. Coli heavily relies on proper modeling. Our Dry-Lab team has spent its summer setting up a computational model of Dr. Coli to completely simulate his actions. We constructed models of all the subsystems (components) in both CellDesigner and Matlab. All these subsystems have been characterised by their ODE's and have been simulated thoroughly. Together they form our full model of Dr. Coli. These models are only capable of simulating the behaviour of one Dr. Coli cell, so we implemented our own Software Tool that can work with multi cellular models.
After building the model frame, it was time to add the physical relevance to it. Kinetic constants were searched for and investigated by means of previous iGEM teams (e.g. ETHZ 2007), the parts characterizations on the Registry of Standard Biological Parts and popular biological literature databases such as Hubmed, ... Our own contribution would revolve around data analysis of the produced parts.
Working with concepts as modularity and abstraction, we worked out every subsystem (Output, Memory, Filter, ...) to eventually merge them all in our full model. By trial and error the system was adapted to achieve desired output quantities (amount of molecules, proteins, ...) given a representative input.
To take it a step further, a multi-cell model was build, to analyse crucial steps in cell division (e.g. Memory inheritance). A diffusion model was made to investigate HSL diffusion towards neighbouring cells and see what effects this generated on their Invertimer system.