Team:KULeuven/Project/CellDeath

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Pictogram celldeath.png

Contents

Cell Death

BioBricks

Project death.jpg

Components

The luxR protein [http://partsregistry.org/Part:BBa_C0062 BBa_C0062] is placed under control of the constitutive promoter [http://partsregistry.org/Part:BBa_J23100 BBa_J23100]. The ccdB suicide gene [http://partsregistry.org/Part:BBa_P1010 BBa_P1010], on its part, is placed under control of the LuxpR promoter [http://partsregistry.org/Part:BBa_R0062 BBa_R0062].

Action

When the concentration of HSL is big enough (see the modeling page), HSL will form a complex with the LuxR protein and thus activate the LuxpR promoter. This results in ccdB production and eventually in cell death ([http://www.ncbi.nlm.nih.gov/pubmed/10196173?dopt=Abstract reference]).



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