Team:Rensselaer/Project

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You are provided with this team page template with which to start the iGEM season.  You may choose to personalize it to fit your team but keep the same "look." Or you may choose to take your team wiki to a different level and design your own wiki.  You can find some examples <a href="https://2008.igem.org/Help:Template/Examples">HERE</a>.
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You <strong>MUST</strong> have a team description page, a project abstract, a complete project description, and a lab notebook.  PLEASE keep all of your pages within your Team:Example namespace. 
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|align="center"|[[Team:Rensselaer | Team Example 2]]
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(''Or you can choose different headings.  But you must have a team page, a project page, and a notebook page.'')
 
== '''Overall project''' ==
== '''Overall project''' ==
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Our team's aim is to obtain color differentiation by cells through their sensing of specific compounds in their media. The cells would respond to the compounds by releasing a visual conformation that would depend upon the type of compound taken in. This visual confirmation is contingent upon the concentration of the compound in the cellular media, which would then trigger the transcription of genes that would release pigments that depended on the type and amount of compound that the cell would sense. Through these methods, we want to induce cell migration depending on the location and concentration of compounds in the media. We believe that these methods can be extrapolated to areas such as bioremediation or for the application of biosensors to test water contamination, given a certain concentration of contaminants. Our project could be further adapted towards the maintenance of homeostasis given metabolic disorders as well as the treatment of metabolic diseases by replacing pigment confirmations with pharmacological proteins.
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Our aim is to develop a novel, micro organism based, sensor using bioinformatics resources and molecular biology techniques. We will genetically modify E. Coli cells to produce various pigments in response to certain compounds in the immediate environment. In addition to simply detecting compounds, we propose to engineer a molecular machine sensitive enough to resolve and even quantify target compound concentrations. This can be achieved in two ways: (1) by measuring color intensity or (2) distinguishing color combinations. We believe that this design can be extrapolated to areas such as bioremediation or for the application of biosensors to test water contamination, given a certain concentration of contaminants. Our project could be further adapted towards the maintenance of homeostasis given metabolic disorders as well as the treatment of metabolic diseases by replacing pigment expression with pharmacological proteins.
== Project Details==
== Project Details==

Latest revision as of 23:09, 28 July 2008

Ls lgp 2c.gif
Home The Team The Project Parts Submitted to the Registry Modeling Notebook


Contents

Overall project

Our aim is to develop a novel, micro organism based, sensor using bioinformatics resources and molecular biology techniques. We will genetically modify E. Coli cells to produce various pigments in response to certain compounds in the immediate environment. In addition to simply detecting compounds, we propose to engineer a molecular machine sensitive enough to resolve and even quantify target compound concentrations. This can be achieved in two ways: (1) by measuring color intensity or (2) distinguishing color combinations. We believe that this design can be extrapolated to areas such as bioremediation or for the application of biosensors to test water contamination, given a certain concentration of contaminants. Our project could be further adapted towards the maintenance of homeostasis given metabolic disorders as well as the treatment of metabolic diseases by replacing pigment expression with pharmacological proteins.

Project Details

Part 2

The Experiments

Part 3

Results

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