Team:ETH Zurich

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== The Team ==
== The Team ==
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The Igem 2008 Team follows the tration of the ETH Teams before, and consits of students of very diverse backgrounds.
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The Team is build up by 4 students with a Biology background and 5 Students with a Informatics/Engineering background.
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If you like to know more about the Team, you will find more Infos in the [https://2008.igem.org/Team:ETH_Zurich/Team/Members Team Section]
[[Image:Team_eth.JPG|left|thumb|150px|Team ETH]]
[[Image:Team_eth.JPG|left|thumb|150px|Team ETH]]
<strong>Undergraduate Students</strong><br>
<strong>Undergraduate Students</strong><br>

Revision as of 23:45, 26 October 2008



Project Abstract

'Random walks towards the minimal genome'

"This year's ETH Zurich project tackles a fundamental problem of synthetic biology: the minimal genome. Exploring the minimal set of genes that is able to support life is not only a question of significant biological interest, it is also a crucial step towards the implementation of orthogonal functionalities into a rationally designed complex biological system. An organism carrying a minimal genome would provide a simple chassis for biological engineering. We attempted to exploit the power of accelerated evolution for a genome reduction strategy. Our approach is based on an iterative cycle of genome reduction and strain selection. We propose a novel method to randomly delete chromosomal DNA fragments by controlled expression of restriction enzymes and ligases in vivo. Furthermore we develop a chemostat-based selective condition to select for cells with a smaller genome size by constraining nucleotide availability. Computationally, we analyze the genome for the optimal restriction enzyme, and perform flux balance analysis on a genome scale model to predict growth of reduced genome strains. Finally, we simulate the restriction enzyme expression and the progression of selection."

The Team

The Igem 2008 Team follows the tration of the ETH Teams before, and consits of students of very diverse backgrounds. The Team is build up by 4 students with a Biology background and 5 Students with a Informatics/Engineering background. If you like to know more about the Team, you will find more Infos in the Team Section

Team ETH

Undergraduate Students
Julia Slipantschuk,Sebastian Giese,Nico Hensgens,Rebecca Herbst,Reine Byun,Georg Ofenbeck
Graduate Students
Sven Lucas Dietz,Luca Gerosa,[http://www.biol.ethz.ch/IMB/groups/ban_group/members/jrabl Julius Rabl]
Advisors
[http://www.ipe.ethz.ch/laboratories/bpl/people/panke Sven Panke],[http://www.ipe.ethz.ch/laboratories/bpl/people/meyer Andreas Jörg Meyer],[http://www.csb.ethz.ch/people/joergs Jörg Stelling]

Site Map

Site Map of the ETHZ Side
Home Team Project Wetlab Modeling Tools
Overview Overview Overview Overview Overview Wiki Templates
ETH Zuerich Members Motivation Genome Reduction Framework Automated Wiki
Credits Pictures Background Chemostat Selection Genome Static Analysis
Applications Switch Circuit Genome Scale Model
Conclusions Materials & Methods Chemostat Selection
Medal Relevant Switch Circuit
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