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October 21st

During the week:

I was busy with the estimation of parameters in the steady state with four points in the new model with degradation.

This is the new model :

e= alpha * T^m / (K^m+T^m)*(Ki^p+T^p)

so we have 5 parameters (alpha, m, K, p, Ki) to estimate but where as we have just four points from luciferase results we can just estimate four parameters. First I started with estimating alpha,m,K,Ki but couldnt get good results; then I tried alpha,m,K,p and again no improvement. I found out that there is not much sensitivity to alpha but m,K,p and Ki are important so I put some value for alpha and tried to estimate the four rest. Again the best list square residual for s29 (the pink one) was about 10 and for s34 (violet one) was about 4.